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GCLC Antikörper (AA 437-637)

GCLC Reaktivität: Human, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3042420
  • Target Alle GCLC Antikörper anzeigen
    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
    Bindungsspezifität
    • 12
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 437-637
    Reaktivität
    • 67
    • 21
    • 20
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 67
    • 4
    Kaninchen
    Klonalität
    • 60
    • 11
    Polyklonal
    Konjugat
    • 35
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser GCLC Antikörper ist unkonjugiert
    Applikation
    • 53
    • 36
    • 27
    • 17
    • 15
    • 9
    • 9
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Glutamate--cysteine ligase catalytic subunit(GCLC) detection. Tested with WB, IHC-P in Human,Rat.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Glutamate--cysteine ligase catalytic subunit(GCLC) detection. Tested with WB, IHC-P in Human,Rat.
    Gene Name: glutamate-cysteine ligase, catalytic subunit
    Protein Name: Glutamate--cysteine ligase catalytic subunit
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human GCLC recombinant protein (Position: E437-N637). Human GCLC shares 94% amino acid (aa) sequence identity with both mouse and rat GCLC.
    Isotyp
    IgG
    Top Product
    Discover our top product GCLC Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for GCLC is approximately 0.2 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Ni, Wang, Qiu, Pang, Song, Guo: "Bone marrow mesenchymal stem cells protect against bleomycin-induced pulmonary fibrosis in rat by activating Nrf2 signaling." in: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7752-61, (2016) (PubMed).

    Jin, Li, Zhang, Wu, Feng, Zhang, Shen: "Electroacupuncture alleviates cerebral ischemia and reperfusion injury via modulation of the ERK1/2 signaling pathway." in: Neural regeneration research, Vol. 11, Issue 7, pp. 1090-8, (2016) (PubMed).

  • Target
    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
    Andere Bezeichnung
    GCLC (GCLC Produkte)
    Synonyme
    GCLC antikoerper, gclc antikoerper, MGC146287 antikoerper, 2259 antikoerper, CG2259 antikoerper, DmGCLC antikoerper, DmGCS antikoerper, DmGCSh antikoerper, Dmel\\CG2259 antikoerper, GCL antikoerper, GCLc antikoerper, GCSh antikoerper, Gcs antikoerper, Gcsh antikoerper, DDBDRAFT_0186120 antikoerper, DDBDRAFT_0231403 antikoerper, DDB_0186120 antikoerper, DDB_0231403 antikoerper, GCS antikoerper, GLCL antikoerper, GLCLC antikoerper, D9Wsu168e antikoerper, GLCL-H antikoerper, Ggcs-hs antikoerper, Glclc antikoerper, cb1049 antikoerper, fe36e11 antikoerper, wu:fe36e11 antikoerper, glutamate-cysteine ligase catalytic subunit antikoerper, glutamate-cysteine ligase, catalytic subunit antikoerper, Glutamate-cysteine ligase catalytic subunit antikoerper, gamma glutamylcysteine synthetase antikoerper, glutamate-cysteine ligase, catalytic subunit L homeolog antikoerper, glutamate-cysteine ligase, catalytic subunit S homeolog antikoerper, gamma-glutamylcysteine synthetase antikoerper, GCLC antikoerper, gclc antikoerper, Gclc antikoerper, LbGCS antikoerper, gcsA antikoerper, gclc.L antikoerper, gclc.S antikoerper, GSH1 antikoerper
    Hintergrund
    GCLC, also named Glutamate--cysteine ligase catalytic subunit, is an enzyme that in humans is encoded by the GCLC gene. Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6p12.1. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

    Synonyms: EC 6.3.2.2 antibody|Gamma ECS antibody|Gamma GCS antibody|Gamma glutamylcysteine synthetase antibody|Gamma-ECS antibody|Gamma-glutamylcysteine synthetase antibody|GCL antibody|GCLC antibody|GCLM antibody|GCS antibody|GCS Heavy Chain antibody|GLCL antibody|GLCLC antibody|GLCLR antibody|Glutamate cysteine ligase catalytic subunit antibody|Glutamate cysteine ligase (gamma glutamylcysteine synthetase) regulatory (30.8kD) antibody|Glutamate cysteine ligase catalytic subunit antibody|Glutamate cysteine ligase modifier subunit antibody|Glutamate cysteine ligase regulatory protein antibody|Glutamate cysteine ligase regulatory subunit antibody|Glutamate--cysteine ligase catalytic subunit antibody|GSC light chain antibody|GSH1_HUMAN antibody
    Gen-ID
    2729
    UniProt
    P48506
    Pathways
    Cell RedoxHomeostasis
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