HSPG2 Antikörper (AA 524-701)

Produktnummer ABIN3042466

Produktdetails anti-HSPG2 Antikörper

Target: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Bindungsspezifität: AA 524-701

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSPG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Basement membrane-specific heparan sulfate proteoglycan core protein(HSPG2) detection. Tested with WB, IHC-P in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Basement membrane-specific heparan sulfate proteoglycan core protein(HSPG2) detection. Tested with WB, IHC-P in Human.
Gene Name: heparan sulfate proteoglycan 2
Protein Name: Basement membrane-specific heparan sulfate proteoglycan core protein

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for HSPG2 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu HSPG2

Target: HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))

Andere Bezeichnung: HSPG2 (HSPG2 Produkte)

Synonyme: HSPG antikoerper, PLC antikoerper, PRCAN antikoerper, SJA antikoerper, SJS antikoerper, SJS1 antikoerper, HSPG2 antikoerper, AI852380 antikoerper, Pcn antikoerper, Plc antikoerper, per antikoerper, Per antikoerper, heparan sulfate proteoglycan 2 antikoerper, perlecan (heparan sulfate proteoglycan 2) antikoerper, HSPG2 antikoerper, hspg2 antikoerper, Hspg2 antikoerper

Hintergrund: Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

Synonyms: Basement membrane specific heparan sulfate proteoglycan core protein antibody|Endorepellin (domain V region) antibody|Heparan Sulfate Proteoglycan antibody|Heparan sulfate proteoglycan of basement membrane antibody|HSPG 2 antibody|HSPG antibody|Hspg2 antibody|LG3 peptide antibody|Perlecan antibody|PGBM_HUMAN antibody|PLC antibody|Schwartz Jampel syndrome 1 (chondrodystrophic myotonia) antibody|SJA antibody|SJS antibody|SJS1 antibody

Gen-ID: 3339

UniProt: P98160

Pathways: Glycosaminoglycan Metabolic Process, Lipid Metabolism