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Otoferlin Antikörper (C-Term)

OTOF Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3042499
  • Target Alle Otoferlin (OTOF) Antikörper anzeigen
    Otoferlin (OTOF)
    Bindungsspezifität
    • 1
    • 1
    • 1
    AA 1831-1863, C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 1
    • 1
    Kaninchen
    Klonalität
    • 1
    • 1
    Polyklonal
    Konjugat
    • 2
    Dieser Otoferlin Antikörper ist unkonjugiert
    Applikation
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Otoferlin(OTOF) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequenz
    QIWDADHFSA DDFLGAIELD LNRFPRGAKT AKQ
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Otoferlin(OTOF) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: otoferlin
    Protein Name: Otoferlin
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human Otoferlin (1831-1863aa QIWDADHFSADDFLGAIELDLNRFPRGAKTAKQ), identical to the related mouse and rat sequences.
    Isotyp
    IgG
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    Otoferlin (OTOF)
    Andere Bezeichnung
    OTOF (OTOF Produkte)
    Synonyme
    OTOF antikoerper, Otof antikoerper, AUNB1 antikoerper, DFNB6 antikoerper, DFNB9 antikoerper, FER1L2 antikoerper, NSRD9 antikoerper, fj34b10 antikoerper, si:dkey-181f18.3 antikoerper, wu:fj34b10 antikoerper, otoferlin antikoerper, putative otoferlin antikoerper, otoferlin a antikoerper, OTOF antikoerper, LOC5565414 antikoerper, CpipJ_CPIJ002471 antikoerper, CpipJ_CPIJ010863 antikoerper, Smp_163750 antikoerper, otof antikoerper, Otof antikoerper, otofa antikoerper
    Hintergrund
    Otoferlin is a protein that in humans is encoded by the OTOF gene. Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multipleisoforms have been found for this gene.

    Synonyms: AUNB1 antibody|Deafness, autosomal recessive 9 antibody|DFNB6 antibody|DFNB9 antibody|Fer 1 like protein 2 antibody|Fer-1-like protein 2 antibody|FER1L2 antibody|NSRD9 antibody|Otof antibody|OTOF_HUMAN antibody|Otoferlin antibody
    Gen-ID
    9381
    Pathways
    Sensory Perception of Sound, Synaptic Vesicle Exocytosis
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