CTGF Antikörper (AA 58-349)

Produktnummer ABIN3042771

Produktdetails anti-CTGF Antikörper

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Bindungsspezifität: AA 58-349

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTGF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Connective tissue growth factor(CTGF) detection. Tested with WB, IHC-P in Human,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Connective tissue growth factor(CTGF) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: connective tissue growth factor
Protein Name: Connective tissue growth factor

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CTGF recombinant protein (Position: R58-A349). Human CTGF shares 95.5% and 95.9% amino acid (aa) sequence identity with mouse and rat CTGF, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-CTGF Antikörper (ABIN3042771)

Lu, Kang, Hu, Tang, Zhou, Yu, Xu: "Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis." in: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, Vol. 50, Issue 1, pp. e5594, (2017) (PubMed).

Lv, Wu, Li, Wang, Wang, Zhang, Xu, Zhang: "Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats." in: Biomedicine & pharmacotherapy, Vol. 88, pp. 894-901, (2017) (PubMed).

Zhang, Li, Zheng, Lin, Zhang, Zhang: "Inhibition of angiogenesis by arsenic trioxide via TSP-1-TGF-β1-CTGF-VEGF functional module in rheumatoid arthritis." in: Oncotarget, Vol. 8, Issue 43, pp. 73529-73546, (2017) (PubMed).

Yang, Luo, Zhu, Zhou, Wang, Xue, Zhang, Cai, Chen, Ma, Chen, Wang, Luo, Liu, Zhao: "Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 8, pp. 929, (2017) (PubMed).

Bai, Li, Zhao, Liu, Wang, Lian, Zhao, Wang: "PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor." in: Oncotarget, Vol. 8, Issue 67, pp. 111642-111655, (2017) (PubMed).

Cheng, Xiao, Ainiwaer, Wang, Wu, Mao, Yang, Bao: "Molecular responses of radiation-induced liver damage in rats." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 2592-600, (2015) (PubMed).

Ma, Li, Yue, Guo, Xu, Xu, Jia, Yu, Zhang, Liu, Liu, Shao, Chen, Liu: "Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4." in: Journal of cardiovascular pharmacology, Vol. 64, Issue 1, pp. 28-37, (2014) (PubMed).

Jin, Shi, Zou, Miao, Sun, Li: "Fenugreek Prevents the Development of STZ-Induced Diabetic Nephropathy in a Rat Model of Diabetes." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 259368, (2014) (PubMed).

Wang, Zhuang, Gao, Zhang, Yang: "Increased expression of CCN2 in the red flashing light-induced myopia in guinea pigs." in: BioMed research international, Vol. 2013, pp. 761823, (2014) (PubMed).

Guo, Qi, Yu, Du, Wu, Liu: "Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats." in: Diabetology & metabolic syndrome, Vol. 6, Issue 1, pp. 29, (2014) (PubMed).

Li, Dai, Zhao, Zhang, Hui, Zhang, Jin: "Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action." in: Experimental and therapeutic medicine, Vol. 6, Issue 4, pp. 904-908, (2013) (PubMed).

Wang, Li, Lu, Zhao, Xu: "Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats." in: Croatian medical journal, Vol. 54, Issue 2, pp. 171-9, (2013) (PubMed).

Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." in: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

Li, Zhang, Wang, Zheng, Chen: "Nicousamide blocks the effects of advanced glycation end products on renal cells." in: European journal of pharmacology, Vol. 674, Issue 2-3, pp. 455-9, (2012) (PubMed).

Wang, Li, Lu, Zhao: "Riboflavin alleviates cardiac failure in Type I diabetic cardiomyopathy." in: Heart international, Vol. 6, Issue 2, pp. e21, (2012) (PubMed).

Wang, Hui, Fan, Xiong, Sun: "Filtering bleb area and intraocular pressure following subconjunctival injection of CTGF antibody after glaucoma filtration surgery in rabbits." in: International journal of ophthalmology, Vol. 4, Issue 5, pp. 480-3, (2012) (PubMed).

Wang, Li, Lu, Bao, Zhao: "Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy." in: Journal of diabetes and its complications, Vol. 26, Issue 4, pp. 259-65, (2012) (PubMed).

Guo, Zhang, Li, Xu: "Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats." in: Cardiovascular diabetology, Vol. 11, pp. 94, (2012) (PubMed).

Details zu CTGF

Target: CTGF (Connective Tissue Growth Factor (CTGF))

Andere Bezeichnung: CTGF (CTGF Produkte)

Synonyme: Ccn2 antikoerper, Fisp12 antikoerper, Hcs24 antikoerper, fisp-12 antikoerper, CCN2 antikoerper, HCS24 antikoerper, IGFBP8 antikoerper, NOV2 antikoerper, CTGRP antikoerper, ctgf antikoerper, hm:zeh1559 antikoerper, si:dkey-266k12.4 antikoerper, wu:fl25c03 antikoerper, zeh1559 antikoerper, zgc:136644 antikoerper, XCTGF antikoerper, ccn2 antikoerper, nov2 antikoerper, hcs24 antikoerper, igfbp8 antikoerper, CTGF antikoerper, si:ch211-173b8.2 antikoerper, connective tissue growth factor antikoerper, connective tissue growth factor a antikoerper, connective tissue growth factor L homeolog antikoerper, connective tissue growth factor b antikoerper, Ctgf antikoerper, CTGF antikoerper, ctgfa antikoerper, ctgf.L antikoerper, ctgf antikoerper, ctgfb antikoerper

Hintergrund: CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. And the encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.

Synonyms: CCN 2 antibody|CCN family member 2 antibody|CCN2 antibody|Connective Tissue Growth Factor antibody|CTGF antibody|CTGF_HUMAN antibody|Hcs 24 antibody|Hcs24 antibody|Hypertrophic chondrocyte specific protein 24 antibody|Hypertrophic chondrocyte-specific gene product 24 antibody|Hypertrophic chondrocyte-specific protein 24 antibody|IBP-8 antibody|IGF-binding protein 8 antibody|IGFBP-8 antibody|IGFBP8 antibody|Insulin like Growth Factor Binding Protein 8 antibody|Insulin-like Growth Factor-Binding Protein 8 antibody|MGC102839 antibody|NOV 2 antibody|NOV2 antibody

Gen-ID: 1490

UniProt: P29279

Pathways: Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Growth Factor Binding