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PAPPA Antikörper (AA 95-388)

PAPPA Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043377
  • Target Alle PAPPA Antikörper anzeigen
    PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
    Bindungsspezifität
    • 15
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 95-388
    Reaktivität
    • 86
    • 22
    Human
    Wirt
    • 46
    • 45
    • 1
    Kaninchen
    Klonalität
    • 47
    • 45
    Polyklonal
    Konjugat
    • 31
    • 14
    • 11
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PAPPA Antikörper ist unkonjugiert
    Applikation
    • 49
    • 45
    • 29
    • 19
    • 13
    • 13
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Pappalysin-1(PAPPA) detection. Tested with WB, IHC-P in Human.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Pappalysin-1(PAPPA) detection. Tested with WB, IHC-P in Human.
    Gene Name: pregnancy-associated plasma protein A, pappalysin 1
    Protein Name: Pappalysin-1
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human PAPP A recombinant protein (Position: R95-Q388). Human PAPP A shares 88% amino acid (aa) sequence identity with mouse PAPP A.
    Isotyp
    IgG
    Top Product
    Discover our top product PAPPA Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for PAPP A is approximately 0.25 ng/lane under reducing conditions.
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
    Andere Bezeichnung
    PAPPA (PAPPA Produkte)
    Synonyme
    8430414N03Rik antikoerper, IGFBP-4ase antikoerper, PAG1 antikoerper, PAPP-A antikoerper, ASBABP2 antikoerper, DIPLA1 antikoerper, PAPA antikoerper, PAPPA1 antikoerper, Pappa antikoerper, pappalysin 1 antikoerper, pregnancy-associated plasma protein A antikoerper, PAPPA antikoerper, Pappa antikoerper, Pappa1 antikoerper
    Hintergrund
    Pappalysin-1, also known as DIPLA1, is a protein that in humans is encoded by the PAPPA gene. It is mapped to 9q33.1. PAPPA is found in the ovarian follicles, follicular fluid, luteal cells, and fallopian tubes of nonpregnant women and in the seminal vesicles and seminal fluid of males. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. It has been found that circulating PAPPA is a disulfide-bridged complex with proMBP in which the subunits of the constituents are present in a 1:1 Molar ratio.

    Synonyms: ASBABP2 antibody|Aspecific BCL2 ARE binding protein 2 antibody|Differentially placenta 1 expressed protein antibody|DIPLA1 antibody|IGF dependent IGFBP 4 protease antibody|IGF-dependent IGFBP-4 protease antibody|IGFBP 4ase antibody|IGFBP-4ase antibody|IGFBP4ase antibody|Insulin like growth factor dependent IGF binding protein 4 protease antibody|Insulin-like growth factor-dependent IGF-binding protein 4 protease antibody|PAPA antibody|PAPP A antibody|PAPP-A antibody|PAPP1_HUMAN antibody|PAPPA antibody|PAPPA1 antibody|Pappalysin 1 precursor antibody|Pappalysin-1 antibody|Pregnancy Associated Plasma Protein A antibody|Pregnancy associated plasma protein A pappalysin 1 antibody|Pregnancy-associated plasma protein A antibody
    Gen-ID
    5069
    UniProt
    Q13219
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