Tumor Protein p73 Antikörper (AA 1-198)

Produktnummer ABIN3043469

Produktdetails anti-Tumor Protein p73 Antikörper

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Bindungsspezifität: AA 1-198

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Tumor Protein p73 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: tumor protein p73
Protein Name: Tumor protein p73

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human p73 recombinant protein (Position: M1-E198). Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for p73 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-Tumor Protein p73 Antikörper (ABIN3043469)

Guo, Nan, Hu, Meng, Hui, Zhang, Qin, Sui: "Prognostic significance of co-expression of nm23 and p57 protein in hepatocellular carcinoma." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 40, Issue 11, pp. 1107-16, (2010) (PubMed).

Qin, Nan, Yang, Jing, Ruan, Li, Xu, Guo, Sui, Wei: "Expression and clinical significance of TAp73alpha, p53, PCNA and apoptosis in hepatocellular carcinoma." in: World journal of gastroenterology, Vol. 11, Issue 18, pp. 2709-13, (2005) (PubMed).

Details zu Tumor Protein p73

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Andere Bezeichnung: TP73 (TP73 Produkte)

Synonyme: P73 antikoerper, Trp73 antikoerper, TP73 antikoerper, tp73 antikoerper, Tp73 antikoerper, p73 antikoerper, TAp73 antikoerper, zp73theta antikoerper, tumor protein p73 antikoerper, transformation related protein 73 antikoerper, TP73 antikoerper, Tp73 antikoerper, tp73 antikoerper, Trp73 antikoerper

Hintergrund: P73, also known as tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation.

Synonyms: p53 like transcription factor antibody|p53 Related Protein antibody|p53 Related Protein antibody|p53-like transcription factor antibody|p53-related protein antibody|p73 antibody|P73_HUMAN antibody|TP 73 antibody|TP73 antibody|TP73 antibody|Tumor Protein p73 antibody|Tumor Protein p73 antibody

Gen-ID: 7161

UniProt: O15350

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus