Cyclin A1 Antikörper (AA 64-263)

Produktnummer ABIN3043480

Produktdetails anti-Cyclin A1 Antikörper

Target: Cyclin A1 (CCNA1)

Bindungsspezifität: AA 64-263

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Cyclin-A1(CCNA1) detection. Tested with WB in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Cyclin-A1(CCNA1) detection. Tested with WB in Human.
Gene Name: cyclin A1
Protein Name: Cyclin-A1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Cyclin A1 recombinant protein (Position: D64-E263). Human Cyclin A1 shares 78.5% and 79.5% amino acid (aa) sequence identity with mouse and rat Cyclin A1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-Cyclin A1 Antikörper (ABIN3043480)

Zeng, Ma, Chen, Qiu, Wu, Ling, Zeng: "Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury." in: Journal of biomedical materials research. Part A, Vol. 104, Issue 8, pp. 1902-11, (2017) (PubMed).

Yuan, Zheng, Li, Xiang, Gao, Ran, Sun, Huang, Xie, Du, Xiao: "Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2." in: Acta biochimica et biophysica Sinica, Vol. 48, Issue 3, pp. 220-8, (2016) (PubMed).

Details zu Cyclin A1

Target: Cyclin A1 (CCNA1)

Andere Bezeichnung: CCNA1 (CCNA1 Produkte)

Synonyme: fd14f08 antikoerper, wu:fd14f08 antikoerper, wu:fi20d12 antikoerper, zgc:111869 antikoerper, MGC81965 antikoerper, cyclin-A1 antikoerper, CCNA1 antikoerper, MGC132235 antikoerper, cyclin-A1-2 antikoerper, Cyclin-A1 antikoerper, ccna1 antikoerper, cyclin A1 antikoerper, cyclin A1 L homeolog antikoerper, CYCLIN A1;2 antikoerper, cyclin A1 S homeolog antikoerper, CCNA1 antikoerper, ccna1 antikoerper, ccna1.L antikoerper, CYCA1;2 antikoerper, Ccna1 antikoerper, ccna1.S antikoerper

Hintergrund: Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. Also this cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: CCN A1 antibody|CCNA 1 antibody|CCNA1 antibody|CCNA1_HUMAN antibody|Cyclin-A1 antibody| CyclinA1 antibody|G2/mitotic specific cyclin A1 antibody|MGC132235 antibody|MGC159139 antibody

Gen-ID: 8900

UniProt: P78396

Pathways: Apoptose, Zellzyklus, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA