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TdT Antikörper (AA 316-509)

DNTT Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043577
  • Target Alle TdT (DNTT) Antikörper anzeigen
    TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
    Bindungsspezifität
    • 16
    • 12
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 316-509
    Reaktivität
    • 86
    • 19
    • 19
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Wirt
    • 72
    • 15
    Kaninchen
    Klonalität
    • 69
    • 18
    Polyklonal
    Konjugat
    • 41
    • 8
    • 7
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser TdT Antikörper ist unkonjugiert
    Applikation
    • 53
    • 44
    • 10
    • 9
    • 8
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for DNA nucleotidylexotransferase(DNTT) detection. Tested with WB in Human.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for DNA nucleotidylexotransferase(DNTT) detection. Tested with WB in Human.
    Gene Name: DNA nucleotidylexotransferase
    Protein Name: DNA nucleotidylexotransferase
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human TdT recombinant protein (Position: K316-A509). Human TdT shares 81% amino acid (aa) sequence identity with mouse TdT.
    Isotyp
    IgG
    Top Product
    Discover our top product DNTT Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for TdT is approximately 0.25 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Yang, Zhang, Ding, Huang, Chen, Wu, Wang, Wang, Chen: "Antitumour activity of the recombination polypeptide GST-NT21MP is mediated by inhibition of CXCR4 pathway in breast cancer." in: British journal of cancer, Vol. 110, Issue 5, pp. 1288-97, (2014) (PubMed).

    Zhang, Pei, Ru, Li, Liu: "Bone morphogenetic protein 7 upregulates the expression of nestin and glial fibrillary acidic protein in rats with cerebral ischemia-reperfusion injury." in: Biomedical reports, Vol. 1, Issue 6, pp. 895-900, (2014) (PubMed).

    Tochinai, Ando, Suzuki, Suzuki, Nagata, Hata, Uchida, Kobayashi, Kado, Kaneko: "Histopathological studies of microtubule disassembling agent-induced myocardial lesions in rats." in: Experimental and toxicologic pathology : official journal of the Gesellschaft fu?r Toxikologische Pathologie, Vol. 65, Issue 6, pp. 737-43, (2013) (PubMed).

    Zeng, Ke, Song, Yao, Hu, Zhang, Li, Yin: "Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance." in: Experimental and molecular pathology, Vol. 95, Issue 1, pp. 23-31, (2013) (PubMed).

    Xi, Wang, Ye, Luo, Ning: "Combined adenovirus-mediated artificial microRNAs targeting mfgl2, mFas, and mTNFR1 protect against fulminant hepatic failure in mice." in: PLoS ONE, Vol. 8, Issue 11, pp. e82330, (2013) (PubMed).

    Gong, Zheng, Wang, Chen, Pang, Hu, Cao: "Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model." in: World journal of gastroenterology, Vol. 18, Issue 35, pp. 4934-43, (2012) (PubMed).

    Luo, Xia: "A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol." in: Anesthesia and analgesia, Vol. 103, Issue 1, pp. 110-6, table of contents, (2006) (PubMed).

    Luo, Xia, Ansley, Ouyang, Granville, Li, Xia, Zhou, Liu: "Propofol dose-dependently reduces tumor necrosis factor-alpha-Induced human umbilical vein endothelial cell apoptosis: effects on Bcl-2 and Bax expression and nitric oxide generation." in: Anesthesia and analgesia, Vol. 100, Issue 6, pp. 1653-9, (2005) (PubMed).

    Xu, Liu, Gao, Zhang, Wang, Cao: "Possible mechanisms of the protection of ginsenoside Re against MPTP-induced apoptosis in substantia nigra neurons of Parkinson's disease mouse model." in: Journal of Asian natural products research, Vol. 7, Issue 3, pp. 215-24, (2004) (PubMed).

  • Target
    TdT (DNTT) (Deoxynucleotidyltransferase, terminal (DNTT))
    Andere Bezeichnung
    DNTT (DNTT Produkte)
    Synonyme
    TdT antikoerper, TDT antikoerper, BB160593 antikoerper, Tdt antikoerper, dntt-A antikoerper, dntt antikoerper, DNA nucleotidylexotransferase antikoerper, deoxynucleotidyltransferase, terminal antikoerper, DNA nucleotidylexotransferase L homeolog antikoerper, terminal deoxynucleotidyl transferase antikoerper, DNTT antikoerper, dntt antikoerper, Dntt antikoerper, dntt.L antikoerper, tdt antikoerper
    Hintergrund
    Terminal Deoxynucleotidyl Transferase, also known as TDT and terminal transferase, is a unique DNA polymerase without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. Its gene is mapped to the region 10q23-q24. And TDT cDNA contains an open reading frame of 1,530 basepairs corresponding to a protein containing 510 amino acids. TDT may be responsible for inserting nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells. Additionally, TDT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. Unlike most DNA polymerases it does not require a template. The preferred substrate of this enzyme is a 3'-overhang, but it can also add nucleotides to blunt or recessed 3' ends. Cobalt is a necessary cofactor.

    Synonyms: Deoxynucleotidyltransferase terminal antibody|DNA nucleotidylexotransferase antibody|DNTT antibody|Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody|TDT antibody|TDT_HUMAN antibody|Terminal addition enzyme antibody|Terminal deoxynucleotidyltransferase antibody|Terminal deoxyribonucleotidyltransferase antibody|Terminal transferase antibody
    Gen-ID
    1791
    UniProt
    P04053
    Pathways
    DNA Reparatur
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