COMT Antikörper (AA 52-271)

Produktnummer ABIN3043815

Produktdetails anti-COMT Antikörper

Target: COMT (Catechol-O-Methyltransferase (COMT))

Bindungsspezifität: AA 52-271

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COMT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Verwendungszweck: Rabbit IgG polyclonal antibody for Catechol O-methyltransferase(COMT) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Catechol O-methyltransferase(COMT) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: catechol-O-methyltransferase
Protein Name: Catechol O-methyltransferase

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human COMT recombinant protein (Position: G52-P271). Human COMT shares 81.9% and 81% amino acid (aa) sequence identity with mouse and rat COMT, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu COMT

Target: COMT (Catechol-O-Methyltransferase (COMT))

Andere Bezeichnung: COMT (COMT Produkte)

Synonyme: Comt1 antikoerper, D16Wsu103e antikoerper, D330014B15Rik antikoerper, COMT antikoerper, mb-comt antikoerper, s-comt antikoerper, comt antikoerper, MGC154444 antikoerper, zgc:114157 antikoerper, si:dkey-13a21.15 antikoerper, zK13A21.15 antikoerper, zgc:162236 antikoerper, catechol-O-methyltransferase antikoerper, microRNA 4761 antikoerper, catechol-O-methyltransferase S homeolog antikoerper, methyltransferase antikoerper, catechol-o-methyltransferase antikoerper, catechol-O-methyltransferase a antikoerper, catechol-O-methyltransferase b antikoerper, catechol O-methyltransferase antikoerper, COMT antikoerper, Comt antikoerper, MIR4761 antikoerper, comt antikoerper, comt.2 antikoerper, comt.S antikoerper, Rv1703c antikoerper, Mb1729c antikoerper, comta antikoerper, comtb antikoerper, LOC100354142 antikoerper

Hintergrund: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.

Synonyms: Catechol O methyltransferase antibody|Catechol O-methyltransferase antibody|COMT antibody| COMT_HUMAN antibody|EC 2.1.1.6 antibody

Gen-ID: 1312

UniProt: P21964

Pathways: Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interaktom