HDAC11 Antikörper (N-Term)

Produktnummer ABIN3043840

Produktdetails anti-HDAC11 Antikörper

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Bindungsspezifität: AA 47-81, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Histone deacetylase 11(HDAC11) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: NFLKEEKLLS DSMLVEAREA SEEDLLVVHT RRYLN

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Histone deacetylase 11(HDAC11) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: histone deacetylase 11
Protein Name: Histone deacetylase 11

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human HDAC11 (47-81aa NFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLN), different from the related mouse sequence by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Rat, Predicted Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu HDAC11

Target: HDAC11 (Histone Deacetylase 11 (HDAC11))

Andere Bezeichnung: HDAC11 (HDAC11 Produkte)

Synonyme: CG31119 antikoerper, DHDACX antikoerper, Dmel\\CG31119 antikoerper, HDAC11 antikoerper, HDACX antikoerper, dHDAC11 antikoerper, dmHDA403 antikoerper, zgc:91942 antikoerper, HD11 antikoerper, histone deacetylase 11 antikoerper, Histone deacetylase 11 antikoerper, hypothetical protein antikoerper, HDAC11 antikoerper, hdac11 antikoerper, CpipJ_CPIJ001619 antikoerper, Bm1_15905 antikoerper, LOAG_18214 antikoerper, Hdac11 antikoerper

Hintergrund: Histone deacetylase 11 is a 39 kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This gene encodes a class IV histone deacetylase. And the encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells. In addition, HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.

Synonyms: FLJ22237 antibody|HD 11 antibody|HD11 antibody|HDA11_HUMAN antibody|HDAC 11 antibody|HDAC11 antibody|Histone deacetylase 11 antibody

Gen-ID: 79885