PTH1R Antikörper (C-Term)

Produktnummer ABIN3043983

Produktdetails anti-PTH1R Antikörper

Target: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Bindungsspezifität: AA 388-406, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTH1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Verwendungszweck: Rabbit IgG polyclonal antibody for Parathyroid hormone/parathyroid hormone-related peptide receptor(PTH1R) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Sequenz: KLRETNAGRC DTRQQYRKL

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Parathyroid hormone/parathyroid hormone-related peptide receptor(PTH1R) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: parathyroid hormone 1 receptor
Protein Name: Parathyroid hormone/parathyroid hormone-related peptide receptor

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Parathyroid Hormone Receptor 1(388-406aa KLRETNAGRCDTRQQYRKL), identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-PTH1R Antikörper (ABIN3043983)

Ma, Wu, Jin: "The association between parathyroid hormone 1‑34 and the Wnt/β‑catenin signaling pathway in a rat model of osteoarthritis." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 8799-8807, (2018) (PubMed).

Wang, Wang, Dai, Chen, Yang, Dai, Ou, Wang, Lin: "Effects of Intermittent Administration of Parathyroid Hormone (1-34) on Bone Differentiation in Stromal Precursor Antigen-1 Positive Human Periodontal Ligament Stem Cells." in: Stem cells international, Vol. 2016, pp. 4027542, (2016) (PubMed).

Li, He, Yao, Song, Zeng, Peng, Rosol, Deng: "TGF-? Induces Degradation of PTHrP Through Ubiquitin-Proteasome System in Hepatocellular Carcinoma." in: Journal of Cancer, Vol. 6, Issue 6, pp. 511-8, (2015) (PubMed).

Details zu PTH1R

Target: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Andere Bezeichnung: PTH1R (PTH1R Produkte)

Synonyme: PFE antikoerper, PTHR antikoerper, PTHR1 antikoerper, PPR antikoerper, Pthr antikoerper, Pthr1 antikoerper, pthr1 antikoerper, zPTH1R antikoerper, PTHrel antikoerper, PTH1 antikoerper, PTH antikoerper, parathyroid hormone 1 receptor antikoerper, parathyroid hormone 1 receptor a antikoerper, PTH1R antikoerper, Pth1r antikoerper, pth1ra antikoerper

Hintergrund: Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as PTH1R, PTHR, is a protein that in humans is encoded by the PTH1R gene. PTHR is a member of a family of G protein-coupled receptors. PTHR gene was mapped to the vicinity of the 3p21.3-p21.2 boundary by PCR analysis of human/rodent somatic cell hybrid panels using oligonucleotide primers designed to amplify a portion of the gene from genomic DNA. This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. PTH1R functions as a receptor for parathyroid hormone and for parathyroid hormone-related protein.

Synonyms: MGC138426 antibody|MGC138452 antibody|Parathyroid hormone 1 receptor antibody|Parathyroid hormone/parathyroid hormone related peptide receptor antibody|Parathyroid hormone/parathyroid hormone related protein receptor antibody|Parathyroid hormone/parathyroid hormone-related peptide receptor antibody|PTH receptor antibody|PTH/PTHr receptor antibody|PTH/PTHrP receptor antibody|PTH/PTHrP type I receptor antibody|PTH1 receptor antibody|PTH1R antibody|PTH1R_HUMAN antibody|PTHR 1 antibody|PTHR antibody|PTHR1 antibody

UniProt: Q03431

Pathways: Regulation of Carbohydrate Metabolic Process