CD1d Antikörper (N-Term)

Produktnummer ABIN3044081

Produktdetails anti-CD1d Antikörper

Target: CD1d (CD1D) (CD1d Molecule (CD1D))

Bindungsspezifität: AA 76-92, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD1d Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Antigen-presenting glycoprotein CD1d(CD1D) detection. Tested with WB, IHC-P in Human.

Sequenz: FSDQQWETLQ HIFRVYR

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Antigen-presenting glycoprotein CD1d(CD1D) detection. Tested with WB, IHC-P in Human.
Gene Name: CD1d molecule
Protein Name: Antigen-presenting glycoprotein CD1d

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CD1d(76-92aa FSDQQWETLQHIFRVYR).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for CD1D is approximately 2.5 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu CD1d

Target: CD1d (CD1D) (CD1d Molecule (CD1D))

Andere Bezeichnung: CD1D (CD1D Produkte)

Synonyme: CD1A antikoerper, R3 antikoerper, CD1D antikoerper, CD1D1 antikoerper, CD1d molecule antikoerper, CD1D antigen, d polypeptide antikoerper, CD1D antikoerper

Hintergrund: CD1D(CD1d molecule) also known as R3G1, Antigen-presenting glycoprotein CD1d, R3G1, CD1D, is the sole group-2 member of the CD1 family of major histocompatibility(MHC)-like glycoproteins. Expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 Molecules. CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T(NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production. Jayawardena-Wolf et al. described 2 different pathways of Cd1d trafficking to endosomal compartments in mouse cells. A tyrosine-based motif governs recycling between the plasma membrane and the endosome, while Cd1d associates, like major histocompatibility complex class II antigens, with the invariant chain, or II, in the endoplasmic reticulum. Both pathways enhance antigen presentation to Cd1d-restricted natural killer T cells.

Synonyms: Antigen-presenting glycoprotein CD1d antibody|CD1.1 antibody|CD1A antibody|CD1d antibody|CD1D antigen antibody|CD1D antigen d polypeptide antibody|CD1d molecule antibody|CD1D_HUMAN antibody|Cd1d1 antibody|Differentiation antigen CD1 alpha 3 antibody|HMC class I antigen like glycoprotein CD1D antibody|Ly 38 antibody|MGC34622 antibody|R3 antibody|R3G1 antibody|T cell surface glycoprotein CD1d antibody|T cell surface glycoprotein CD1d precursor antibody|Thymocyte antigen CD1D antibody

UniProt: P15813

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process