DPYD Antikörper (N-Term)

Produktnummer ABIN3044151

Produktdetails anti-DPYD Antikörper

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Bindungsspezifität: AA 33-52, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DPYD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase[NADP(+)](DPYD) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: AKKLDKKHWK RNPDKNCFNC

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase[NADP(+)](DPYD) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: dihydropyrimidine dehydrogenase
Protein Name: Dihydropyrimidine dehydrogenase [NADP(+)](DHPDHase/DPD)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human DPYD(33-52aa AKKLDKKHWKRNPDKNCFNC), different from the related rat and mouse sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu DPYD

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Andere Bezeichnung: DPYD (DPYD Produkte)

Synonyme: DPYD antikoerper, dpyd antikoerper, zgc:77205 antikoerper, AI315208 antikoerper, DPD antikoerper, E330028L06Rik antikoerper, DHP antikoerper, DHPDHASE antikoerper, dhp antikoerper, dhpdhase antikoerper, dpd antikoerper, 14.t00017 antikoerper, DDBDRAFT_0189681 antikoerper, DDBDRAFT_0231100 antikoerper, DDB_0189681 antikoerper, DDB_0231100 antikoerper, dpyda antikoerper, zgc:153505 antikoerper, dihydropyrimidine dehydrogenase antikoerper, dihydropyrimidine dehydrogenase b antikoerper, dihydropyrimidine dehydrogenase L homeolog antikoerper, dihydropyrimidine dehydrogenase [NADP(+)] antikoerper, dihydropyrimidine dehydrogenase a, tandem duplicate 1 antikoerper, DPYD antikoerper, Dpyd antikoerper, dpydb antikoerper, dpyd.L antikoerper, EHI_012980 antikoerper, LOC5573038 antikoerper, EDI_044620 antikoerper, pyd1 antikoerper, dpyda.1 antikoerper

Hintergrund: DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

Synonyms: DHP antibody|DHPDHase antibody|Dihydropyrimidine dehydrogenase[NADP(+)] antibody|Dihydropyrimidine dehydrogenase[NADP+] antibody|Dihydropyrimidine dehydrogenase antibody|Dihydrothymine dehydrogenase antibody|Dihydrouracil dehydrogenase antibody|DPD antibody|DPYD antibody|DPYD_HUMAN antibody|MGC132008 antibody|MGC70799 antibody|OTTHUMP00000058954 antibody

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process