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GLI3 Antikörper (N-Term)

GLI3 Reaktivität: Human, Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044156
  • Target Alle GLI3 Antikörper anzeigen
    GLI3 (GLI Family Zinc Finger 3 (GLI3))
    Bindungsspezifität
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 40-57, N-Term
    Reaktivität
    • 44
    • 24
    • 16
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 37
    • 5
    • 3
    Kaninchen
    Klonalität
    • 33
    • 12
    Polyklonal
    Konjugat
    • 24
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser GLI3 Antikörper ist unkonjugiert
    Applikation
    • 17
    • 13
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Rabbit IgG polyclonal antibody for Transcriptional activator GLI3(GLI3) detection. Tested with WB in Human,Mouse,Rat.
    Sequenz
    SNEDESPGQT YHRERRNA
    Kreuzreaktivität (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Transcriptional activator GLI3(GLI3) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: GLI family zinc finger 3
    Protein Name: Transcriptional activator GLI3
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human Gli3(40-57aa SNEDESPGQTYHRERRNA), different from the related rat sequence by two amino acids, and from the related mouse sequence by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product GLI3 Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Haltbarkeit
    12 months
  • Kumari, Chaurasia, Kumar, Dash: "Anti-apoptotic role of sonic hedgehog on blood platelets." in: Thrombosis research, Vol. 134, Issue 6, pp. 1311-5, (2014) (PubMed).

  • Target
    GLI3 (GLI Family Zinc Finger 3 (GLI3))
    Andere Bezeichnung
    GLI3 (GLI3 Produkte)
    Synonyme
    ACLS antikoerper, GCPS antikoerper, GLI3-190 antikoerper, GLI3FL antikoerper, PAP-A antikoerper, PAPA antikoerper, PAPA1 antikoerper, PAPB antikoerper, PHS antikoerper, PPDIV antikoerper, xgli3 antikoerper, AI854843 antikoerper, AU023367 antikoerper, Bph antikoerper, Pdn antikoerper, Xt antikoerper, add antikoerper, im:7142603 antikoerper, GLI3 antikoerper, GLI family zinc finger 3 antikoerper, GLI family zinc finger 3 L homeolog antikoerper, GLI-Kruppel family member GLI3 antikoerper, GLI3 antikoerper, Gli3 antikoerper, gli3.L antikoerper, gli3 antikoerper
    Hintergrund
    GLI3(Gli-kruppel family member 3), also called ONCOGENE GLI3, encodes a member of the zinc finger gene family related to Kruppel, a gene that is known to regulate development in Drosophila. The GLI3 gene is expressed as an 8.5-kb mRNA in tissues such as testis, myometrium, placenta, and lung, and the protein product(relative molecular mass, 190,000) shows sequence-specific DNA binding. The GLI3 gene is mapped on 7p14.1. GLI3 is homologous to the Drosophila cubitus interruptus(ci) gene product(Ci), which regulates the Patched(pct), gooseberry(gsb), and decapentaplegic(dpp) genes. PKA-dependent processing of vertebrate GLI3 in developing limb generates a potent repressor in a manner antagonized by apparent long-range signaling from posteriorly localized Sonic hedgehog protein. The high relative abundance and potency of GLI3 repressor suggested specialization of GLI3 and its products for negative hedgehog pathway regulation.Coimmunoprecipitation and immunoblot studies showed that GLI3 protein is polyubiquitinated and that its processing depends on proteasome activity. The findings suggested that BTRC is required for GLI3 processing.

    Synonyms: ACLS antibody|DNA binding protein antibody|GCPS antibody|Gli 3 antibody|GLI family zinc finger 3 antibody|GLI Kruppel family member GLI 3 antibody|GLI Kruppel family member GLI3(Greig cephalopolysyndactyly syndrome) antibody|GLI Kruppel family member GLI3 antibody|GLI3 antibody|GLI3 C-terminally truncated form antibody|GLI3 form of 190 kDa antibody|GLI3 form of 83 kDa antibody|GLI3 full length protein antibody|GLI3-190 antibody|GLI3-83 antibody|GLI3_HUMAN antibody|GLI3FL antibody|Glioma associated oncogene family zinc finger 3 antibody|Oncogene GLI3 antibody|PAP A antibody|PAPA 1 antibody|PAPA antibody|PAPA1 antibody|PAPB antibody|PHS antibody|PPD IV antibody|PPDIV antibody|Transcriptional activator GLI3 antibody|Transcriptional repressor GLI3R antibody|Zinc finger protein GLI 3 antibody|Zinc finger protein GLI3 antibody
    UniProt
    P10071
    Pathways
    Hedgehog Signalweg
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