Kallikrein 6 Antikörper (C-Term)

Produktnummer ABIN3044157

Produktdetails anti-Kallikrein 6 Antikörper

Target: Kallikrein 6 (KLK6)

Bindungsspezifität: AA 227-244, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kallikrein 6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Verwendungszweck: Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human.

Sequenz: YTNVCRYTNW IQKTIQAK

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Kallikrein-6(KLK6) detection. Tested with WB, IHC-P, ICC in Human.
Gene Name: kallikrein-related peptidase 6
Protein Name: Kallikrein-6

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6(227-244aa YTNVCRYTNWIQKTIQAK).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Kallikrein 6

Target: Kallikrein 6 (KLK6)

Andere Bezeichnung: KLK6 (KLK6 Produkte)

Synonyme: Bssp antikoerper, Klk7 antikoerper, PRSS18 antikoerper, PRSS9 antikoerper, SP59 antikoerper, hK6 antikoerper, Prss9 antikoerper, AI849898 antikoerper, BSP antikoerper, Klk29 antikoerper, MSP antikoerper, Prss18 antikoerper, neurosin antikoerper, kallikrein related peptidase 6 antikoerper, kallikrein related-peptidase 6 antikoerper, kallikrein-6 antikoerper, KLK6 antikoerper, Klk6 antikoerper, LOC100716801 antikoerper

Hintergrund: KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

Synonyms: Bssp antibody|hK 6 antibody|hK6 antibody|Kallikrein 6 precursor antibody|Kallikrein related peptidase 6 antibody|Kallikrein-6 antibody|Kallikrein6 antibody|KLK 6 antibody|Klk 7 antibody|KLK 9 antibody|Klk29 antibody|Klk6 antibody|KLK6_HUMAN antibody|Klk7 antibody|KLK9 antibody|MGC9355 antibody|mGK 1 antibody|mGK1 antibody|MSP antibody|Neurosin antibody|Protease M antibody|Protease serine 18 antibody|Protease serine 9 antibody|PRSS 18 antibody|PRSS 9 antibody|PRSS18 antibody|PRSS9 antibody|Serine protease 18 antibody|Serine protease 9 antibody|SP 59 antibody|SP59 antibody|Tissue kallikrein antibody|TK antibody|Zyme antibody

UniProt: Q92876

Pathways: Komplementsystem, Regulation of G-Protein Coupled Receptor Protein Signaling