SNRPN Antikörper (N-Term)

Produktnummer ABIN3044164

Produktdetails anti-SNRPN Antikörper

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Bindungsspezifität: AA 31-48, N-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNRPN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Verwendungszweck: Rabbit IgG polyclonal antibody for Small nuclear ribonucleoprotein-associated protein N(SNRPN) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Sequenz: FKAFDKHMNL ILCDCDEF

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Small nuclear ribonucleoprotein-associated protein N(SNRPN) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: small nuclear ribonucleoprotein polypeptide N
Protein Name: Small nuclear ribonucleoprotein-associated protein N(snRNP-N)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN(31-48aa FKAFDKHMNLILCDCDEF), identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu SNRPN

Target: SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))

Andere Bezeichnung: SNRPN (SNRPN Produkte)

Synonyme: SNRB' antikoerper, SNRPB' antikoerper, Snrpn antikoerper, zgc:77315 antikoerper, HCERN3 antikoerper, PWCR antikoerper, RT-LI antikoerper, SM-D antikoerper, SMN antikoerper, SNRNP-N antikoerper, SNURF-SNRPN antikoerper, sm-N antikoerper, 2410045I01Rik antikoerper, Peg4 antikoerper, Pwcr1 antikoerper, FE 294 antikoerper, FE 294 psi antikoerper, FE294 antikoerper, FE294 psi antikoerper, SNURF antikoerper, SNRPN antikoerper, QflA-11237 antikoerper, QtrA-10022 antikoerper, Sm-N antikoerper, SmN antikoerper, snRNP-N antikoerper, small nuclear ribonucleoprotein polypeptide-like antikoerper, small nuclear ribonucleoprotein polypeptides B and B1 antikoerper, small nuclear ribonucleoprotein polypeptide N antikoerper, small nuclear ribonucleoprotein N antikoerper, small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 antikoerper, SNRPN upstream reading frame antikoerper, Small nuclear ribonucleoprotein-associated protein N antikoerper, SNRPL antikoerper, snrpb antikoerper, SNRPN antikoerper, Snrpn antikoerper, snrpn antikoerper, SNURF antikoerper

Hintergrund: SNRPN(Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame(SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs(snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

Synonyms: HCERN3 antibody|PWCR antibody|RSMN_HUMAN antibody|RT LI antibody|RTLI antibody|SM D antibody|Sm N antibody|Sm protein D antibody|Sm protein N antibody|Sm-D antibody|Sm-N antibody|Small nuclear ribonucleoprotein associated protein N antibody|Small nuclear ribonucleoprotein polypeptide N antibody|Small nuclear ribonucleoprotein-associated protein N antibody|SMD antibody|SmN antibody|SNRNP N antibody|snRNP-N antibody|SNRNPN antibody|SNRPN antibody|SNURF SNRPN antibody|Tissue specific splicing protein antibody|Tissue-specific-splicing protein antibody

UniProt: P63162