Pleiotrophin Antikörper (C-Term)

Produktnummer ABIN3044398

Produktdetails anti-Pleiotrophin Antikörper

Target: Pleiotrophin (PTN)

Bindungsspezifität: AA 150-168, C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Pleiotrophin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Pleiotrophin(PTN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: QAESKKKKKE GKKQEKMLD

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Pleiotrophin(PTN) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: pleiotrophin
Protein Name: Pleiotrophin(PTN)

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Pleiotrophin(150-168aa QAESKKKKKEGKKQEKMLD), identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-Pleiotrophin Antikörper (ABIN3044398)

Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, (2017) (PubMed).

Details zu Pleiotrophin

Target: Pleiotrophin (PTN)

Andere Bezeichnung: PTN (PTN Produkte)

Synonyme: zHBNF antikoerper, zgc:111787 antikoerper, harp antikoerper, hbnf antikoerper, X-PTF antikoerper, hbgf8 antikoerper, negf1 antikoerper, ptn antikoerper, PTN antikoerper, HARP antikoerper, HBGF8 antikoerper, HBNF antikoerper, NEGF1 antikoerper, PTN-A antikoerper, HB-GAM antikoerper, HBBM antikoerper, HBGF-8 antikoerper, OSF-1 antikoerper, HBBN antikoerper, OSF antikoerper, Osf-1 antikoerper, Osf1 antikoerper, Hbnf antikoerper, pleiotrophin antikoerper, pleiotrophin L homeolog antikoerper, ptn antikoerper, PTN antikoerper, ptn.L antikoerper, Ptn antikoerper

Hintergrund: Pleiotrophin(PTN) also known as heparin-binding brain mitogen(HBBM) or heparin-binding growth factor 8(HBGF-8) or neurite growth-promoting factor 1(NEGF1) or heparin affinity regulatory peptide(HARP) or heparin binding growth associated molecule(HB-GAM) is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.

Synonyms: HARP antibody|HB-GAM antibody|HBBM antibody|HBGAM antibody|HBGF-8 antibody|HBGF8 antibody|HBNF antibody|HBNF-1 antibody|HBNF1 antibody|Heparin binding growth associated molecule antibody|Heparin binding growth factor 8 antibody|Heparin binding neurite outgrowth promoting factor 1 antibody|Heparin-binding brain mitogen antibody|Heparin-binding growth factor 8 antibody|Heparin-binding growth-associated molecule antibody|Heparin-binding neurite outgrowth-promoting factor 1 antibody|NEGF1 antibody|Neurite growth promoting factor 1 antibody|OSF-1 antibody|OSF1 antibody|Osteoblast-specific factor 1 antibody|Pleiotrophin antibody|PTN antibody|PTN_HUMAN antibody

UniProt: P21246

Pathways: RTK Signalweg