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FcRn Antikörper (AA 56-291)

FcRn Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044521
  • Target Alle FcRn Antikörper anzeigen
    FcRn (IgG receptor FcRn (FcRn))
    Bindungsspezifität
    • 14
    • 10
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 56-291
    Reaktivität
    • 42
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 38
    • 9
    • 1
    Kaninchen
    Klonalität
    • 39
    • 9
    Polyklonal
    Konjugat
    • 23
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FcRn Antikörper ist unkonjugiert
    Applikation
    • 29
    • 28
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Verwendungszweck
    Rabbit IgG polyclonal antibody for IgG receptor FcRn large subunit p51(FCGRT) detection. Tested with WB, IHC-P in Human.
    Kreuzreaktivität (Details)
    No cross reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for IgG receptor FcRn large subunit p51(FCGRT) detection. Tested with WB, IHC-P in Human.
    Gene Name: Fc fragment of IgG receptor and transporter
    Protein Name: IgG receptor FcRn large subunit p51
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E. coli-derived human FCGRT recombinant protein (Position: Q56-E291). Human FCGRT shares 70.2% and 68.9% amino acid (aa) sequence identity with mouse and rat FCGRT, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product FcRn Primärantikörper
  • Applikationshinweise
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    FcRn (IgG receptor FcRn (FcRn))
    Andere Bezeichnung
    FCGRT (FcRn Produkte)
    Synonyme
    FCRN antikoerper, alpha-chain antikoerper, FcRn antikoerper, Fc fragment of IgG receptor and transporter antikoerper, Fc receptor, IgG, alpha chain transporter antikoerper, FCGRT antikoerper, Fcgrt antikoerper
    Hintergrund
    IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. In addition, it is postulated that long-range cis inactivation of the FCGRT gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The FCGRT gene is closely situated to the DMPK gene, which is mutant in DM.

    Synonyms: Alpha chain antibody|Fc fragment of IgG, receptor transporter, alpha antibody|FCGRN_HUMAN antibody|FCGRT antibody|FcRn alpha chain antibody|FcRn antibody|FCRN, alpha chain antibody|IgG Fc fragment receptor transporter alpha chain antibody|IgG Gc receptor antibody| IgG receptor FcRn large subunit p51 antibody|IgG receptor FcRn large subunit p51 precursor antibody|Immunoglobulin receptor, intestinal, heavy chain antibody|Neonatal Fc receptor antibody
    Gen-ID
    2217
    UniProt
    P55899
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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