PPP4R1 Antikörper (AA 1-205)

Produktnummer ABIN306662

Produktdetails anti-PPP4R1 Antikörper

Target: PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))

Bindungsspezifität: AA 1-205

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPP4R1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität (Details): Human, mouse, rat

Produktmerkmale: Serine/Threonine-Protein Phosphatase 4 Regulatory Subunit 1, Protein Phosphatase X/A'2, PP4R1,Clone 4A4 binds to all known Isotypes of p63. It is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei). It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80 % of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma. The p63 gene is a homologue of the tumour suppressor gene p53. It is highly expressed in nuclei of basal cells, the progenitor cells of many epithelial tissues. It shows up remarkable structural similarities to p53. By alternative splicing at least 6 different isoforms are synthesised, which are different in the C-terminus (alpha, beta, gamma) and in the N-terminus (TA and DN). In mice loss of the p63 gene leads to inability to form basal cells and severe organic deficits. Similar organic failures occur in humans with autosomal dominant EEC-Syndrome, which obviously is related to mutation of the p63 gene. p63 (6 Isotypes).

Immunogen: Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Pre-treatment of formaldehyde-fixed tissue with Tris-buffered EDTA solution pH 9 or Unmasking Fluid G 40 min at 100 °C,IHC(P),60 min at RT,(liquid conc.) 1:25-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide. The volume is sufficient for 250-500 immunohistochemical tests (100 μL working solution / test). Use appropriate antibody diluent

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu PPP4R1

Target: PPP4R1 (Protein Phosphatase 4, Regulatory Subunit 1 (PPP4R1))

Andere Bezeichnung: Protein Phosphatase 4 R1 (X/A'2) (PPP4R1 Produkte)

Synonyme: MGC55603 antikoerper, zgc:55603 antikoerper, ppp4r1 antikoerper, MGC81597 antikoerper, MGC89421 antikoerper, PPP4R1 antikoerper, MEG1 antikoerper, PP4(Rmeg) antikoerper, PP4R1 antikoerper, 3110001J10Rik antikoerper, Pp4r1 antikoerper, protein phosphatase 4 regulatory subunit 1 antikoerper, protein phosphatase 4, regulatory subunit 1 antikoerper, protein phosphatase 4 regulatory subunit 1 S homeolog antikoerper, PPP4R1 antikoerper, ppp4r1 antikoerper, ppp4r1.S antikoerper, Ppp4r1 antikoerper