Netrin 1 Antikörper
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- Target Alle Netrin 1 (NTN1) Antikörper anzeigen
- Netrin 1 (NTN1)
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Netrin 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Kreuzreaktivität
- Cat, Rind (Kuh), Human, Makake, Maus, Ratte
- Produktmerkmale
- Netrin 1, NTN1,Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis. Netrin 1s main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
- Aufreinigung
- Ammonium Sulfate Precipitation
- Immunogen
- Synthetic peptide derived from the human Netrin 1 protein
- Isotyp
- IgG
- Top Product
- Discover our top product NTN1 Primärantikörper
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- Applikationshinweise
- Antibody can be used for Western blotting (0.5-2 μg/mL). Optimal concentration should be evaluated by serial dilutions.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Target
- Netrin 1 (NTN1)
- Andere Bezeichnung
- Netrin 1 (NTN1 Produkte)
- Synonyme
- ntn1-A antikoerper, Netrin-1 antikoerper, NTN1 antikoerper, unc-6 antikoerper, MGC147073 antikoerper, NTN1L antikoerper, AI561871 antikoerper, BC019633 antikoerper, netrin-1 antikoerper, netrin 1 L homeolog antikoerper, netrin 1 antikoerper, ntn1.L antikoerper, NTN1 antikoerper, ntn1 antikoerper, Ntn1 antikoerper
- NCBI Accession
- NP_004813
- Pathways
- Regulation of Cell Size
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