Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)
Spezifität
This antibody recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. Note that this antibody does not recognise membrane bound complement membrane attack complex. This antibody inhibits lysis of sensitised sheep erythrocytes.
Produktmerkmale
Synonyms: Complement component C7, Complement 7
Aufreinigung
Purified IgG prepared by affinity chromatography on Protein A
C7
Reaktivität: Human
WB, IHC, ICC
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA. Western Blot. Functional Assays: Removal of Sodium Azide is recommended prior to use. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.
The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides.Synonyms: Complement 7, Complement component C7