Uromodulin Antikörper (AA 329-378)

Produktnummer ABIN3180922

Produktdetails anti-Uromodulin Antikörper

Target: Uromodulin (UMOD)

Bindungsspezifität: AA 329-378

Reaktivität: Bitte anfragen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Uromodulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Verwendungszweck: Rabbit polyclonal antibody anti-Uromodulin (329-378 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.

Spezifität: THP Polyclonal Antibody detects endogenous levels of THP protein.

Produktmerkmale: Rabbit Polyclonal to THP.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the human THP at the amino acid range 329-378

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, ELISA 1:10000, IHC-P 1:50-300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C.

Details zu Uromodulin

Target: Uromodulin (UMOD)

Andere Bezeichnung: UMOD (UMOD Produkte)

Synonyme: ADMCKD2 antikoerper, FJHN antikoerper, HNFJ antikoerper, HNFJ1 antikoerper, MCKD2 antikoerper, THGP antikoerper, THP antikoerper, urehr4 antikoerper, uromodulin antikoerper, UMOD antikoerper, Umod antikoerper

Hintergrund: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. Protects against urinary tract infections by binding to type 1 fimbriated E.coli. Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation. Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens.

Molekulargewicht: 70 kDa

Gen-ID: 7369

UniProt: P07911