Tetanus Toxin Antikörper

Produktnummer ABIN318666

Produktdetails anti-Tetanus Toxin Antikörper

Target: Tetanus Toxin (TetX)

Reaktivität: Clostridium tetani

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Tetanus Toxin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects the tetanus toxin which is produced by the soil micro-organism Clostridium tetani. C. tetani infection results in its systemic growth and secretion of tetanus, which causes muscle spasms by inhibiting neurotransmitter release. The antibody also reacts with the C-fragment of tetanus toxin.

Aufreinigung: Affinity Chromatography.

Immunogen: Tetanus Exotoxin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1g/mL. Western Blot: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 5.0 mg/mL

Buffer: PBS pH 7.2 containing 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Tetanus Toxin

Target: Tetanus Toxin (TetX)

Andere Bezeichnung: Tetanus Toxin (TetX Produkte)

Substanzklasse: Bacteria

Hintergrund: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.Synonyms: Clostridium tetani toxin, tetX

Gen-ID: 1061100

NCBI Accession: NP_783831

UniProt: P04958