FAIM3 Antikörper (C-Term)

Produktnummer ABIN318759

Produktdetails anti-FAIM3 Antikörper

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAIM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects an epitope within the C-terminal (CT) region of Human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). In Western Bloting, This antibody detects a band of approximately 43 kDa in Human lung tissue lysate.

Kreuzreaktivität (Details): Species reactivity (expected):Rat and Mouse.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography

Immunogen: A 13 amino acid peptide from near the carboxy terminus of Human Toso. Genename: TOSO

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1 - 2g/mL, detects a band of approximately 43 kDa in human lung tissuelysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FAIM3

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Andere Bezeichnung: FAIM3 / TOSO (FAIM3 Produkte)

Synonyme: FAIM3 antikoerper, FCMR antikoerper, TOSO antikoerper, 1810037B05Rik antikoerper, FcmuR antikoerper, Toso antikoerper, Fc fragment of IgM receptor antikoerper, FCMR antikoerper, Fcmr antikoerper

Hintergrund: Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS PAGE.Synonyms: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso

Gen-ID: 9214

NCBI Accession: NP_001135945

UniProt: O60667