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Aurora A Antikörper (pThr288)

AURKA Reaktivität: Human, Maus IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN319282
  • Target Alle Aurora A (AURKA) Antikörper anzeigen
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Bindungsspezifität
    • 22
    • 11
    • 9
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr288
    Reaktivität
    • 113
    • 67
    • 38
    • 21
    • 18
    • 12
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    Human, Maus
    Wirt
    • 107
    • 18
    • 1
    Kaninchen
    Klonalität
    • 100
    • 25
    Polyklonal
    Konjugat
    • 77
    • 8
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Aurora A Antikörper ist unkonjugiert
    Applikation
    • 91
    • 48
    • 32
    • 25
    • 15
    • 11
    • 10
    • 7
    • 7
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Aurora A (phospho-Thr288) Antibody AP08036PU detects endogenous levels of Aurora A only when phosphorylated at Threonine 288.
    Aufreinigung
    Immunoaffinity Chromatography: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from human Aurora A around the phosphorylation site of Threonine 288 (R-T-TP-L-M).
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  • Applikationshinweise
    Immunohistochemistry (1/50-1/100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at-20 °C.
  • Target
    Aurora A (AURKA) (Aurora Kinase A (AURKA))
    Andere Bezeichnung
    Aurora Kinase A (AURKA Produkte)
    Hintergrund
    Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Synonyms: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6
    Gen-ID
    6790
    NCBI Accession
    NP_003591
    UniProt
    O14965
    Pathways
    Zellzyklus, Asymmetric Protein Localization
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