CDK6 Antikörper (pTyr24)

Produktnummer ABIN319290

Produktdetails anti-CDK6 Antikörper

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Bindungsspezifität: pTyr24

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDK6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Antibody AP08040PU detects endogenous levels of CDK6 only when phosphorylated at Tyrosine 24.

Aufreinigung: Affinity Chromatography

Immunogen: Synthetic phosphopeptide derived from human CDK6 around the phosphorylation site of Tyrosine 24 (G-A-YP-G-K).

Anwendungsinformationen

Applikationshinweise: Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at-20 °C.

Referenzen für anti-CDK6 Antikörper (ABIN319290)

Bychkov, Shulepko, Vasileva, Sudarikova, Kirpichnikov, Lyukmanova: "ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest." in: Acta naturae, Vol. 12, Issue 2, pp. 101-116, (2020) (PubMed).

Bychkov, Shulepko, Osmakov, Andreev, Sudarikova, Vasileva, Pavlyukov, Latyshev, Potapov, Kirpichnikov, Shenkarev, Lyukmanova: "Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a." in: Cancers, Vol. 12, Issue 7, (2020) (PubMed).

Details zu CDK6

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Andere Bezeichnung: CDK6 (CDK6 Produkte)

Hintergrund: Cdk6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE

Gen-ID: 1021

NCBI Accession: NP_001138778

UniProt: Q00534

Pathways: Zellzyklus, Mitotic G1-G1/S Phases