Cofilin Antikörper (Tyr88)
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- Target Alle Cofilin (CFL1) Antikörper anzeigen
- Cofilin (CFL1) (Cofilin 1 (CFL1))
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Bindungsspezifität
- Tyr88
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cofilin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of total Cofilin-1/2 protein.
- Kreuzreaktivität (Details)
- Also reacts to: Cofilin 2
- Aufreinigung
- Immunoaffinity Chromatography.
- Immunogen
- The antiserum was produced against synthesized non-phosphopeptide derived from human Cofilin1/Cofilin2 around the phosphorylation site of Tyrosine 88 (A-T-Yp-E-T).
- Top Product
- Discover our top product CFL1 Primärantikörper
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anti-Cofilin 1 (CFL1) (AA 1-166) antibody
CFL1 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 1A1 unconjugated
anti-Cofilin 1 (CFL1) antibodyKO Validated CFL1 Reaktivität: Human WB, IF, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (AA 3-161) antibodyCFL1 Reaktivität: Human WB, IHC, ICC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (pSer3) antibodyCFL1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (AA 70-98) antibodyCFL1 Reaktivität: Human, Maus WB, FACS Wirt: Kaninchen Polyclonal RB23947 unconjugated
anti-Cofilin 1 (CFL1) (AA 1-100) antibodyCFL1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (AA 2-166) antibodyCFL1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (AA 4-144) antibodyCFL1 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (pSer3) antibodyCFL1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cofilin 1 (CFL1) (AA 4-32), (N-Term) antibodyCFL1 Reaktivität: Human, Maus WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB20525 unconjugated
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- Applikationshinweise
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Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/100approx. 1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50approx. 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store the antibody (in aliquots) at-20 °C.
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- Target
- Cofilin (CFL1) (Cofilin 1 (CFL1))
- Andere Bezeichnung
- Cofilin-1 (CFL1 Produkte)
- Hintergrund
- Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.Synonyms: 18 kDa phosphoprotein, CFL, CFL1, Cofilin non-muscle isoform, p18
- Gen-ID
- 1072
- NCBI Accession
- NP_005498
- UniProt
- P23528
- Pathways
- Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus, CXCR4-mediated Signaling Events
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