EID1
Reaktivität: Human
ELISA, WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
1) Western blotting: ~1 g/mL 2) Immunofluorescence staining: ~1 g/mL Other applications have not been tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
PBS ( pH 7.4), 50 % glycerol. Azide- and carrier-free.
Konservierungsmittel
Azide free
Lagerung
-20 °C
Informationen zur Lagerung
Upon arrival centrifuge briefly and store at -20 C.
Nguyen, Baglia, Huang, Baker, McCance: "Acetylation regulates the differentiation-specific functions of the retinoblastoma protein." in: The EMBO journal, Vol. 23, Issue 7, pp. 1609-18, (2004) (PubMed).
MacLellan, Xiao, Abdellatif, Schneider: "A novel Rb- and p300-binding protein inhibits transactivation by MyoD." in: Molecular and cellular biology, Vol. 20, Issue 23, pp. 8903-15, (2000) (PubMed).
Target
EID1
(EP300 Interacting Inhibitor of Differentiation 1 (EID1))
EID1 (EP300 interacting inhibitor of differentiation 1) encodes a 21 kDa protein, which interacts with RB1 and EP300 and acts as a repressor of MYOD1 transcription. EID1 inhibits EP300 and CBP histone acetyltransferase activity. It may be involved in coupling cell cycle exit to the transcription of genes required for cellular differentiation.