ITPR1 Antikörper (AA 1892-1911)

Produktnummer ABIN337359

Produktdetails anti-ITPR1 Antikörper

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Bindungsspezifität: AA 1892-1911

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITPR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marke: IHC-plus™

Spezifität: Recognizes human IP3R-I. Detects a band of ~240kD by Western Blot. Species cross-reactivity: mouse, rat and canine.

Homologie: Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine (100%) Hamster, Elephant, Panda, Horse (95%) Opossum (85%).

Aufreinigung: Affinity purified

Immunogen: Synthetic peptide corresponding to aa 1892-1911 (N1892KKKDDEVDRDAPSRKKAKE1911) of the cytoplasmic C-terminal domain of human IP3R-I (inositol 1,4,5-triphosphate receptor (type-I)). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine (100%), Hamster, Elephant, Panda, Horse (95%), Opossum (85%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: ICC, IHC, IHC-Fr (1:125), IHC-P (5 μg/mL), IP, WB (1:500)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 5 μg/mL.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 1 mg/mL BSA, 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu ITPR1

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Andere Bezeichnung: ITPR1 / IP3 Receptor Type 1 (ITPR1 Produkte)

Synonyme: D6Pas2 antikoerper, ENSMUSG00000072853 antikoerper, Gm10429 antikoerper, IP3R1 antikoerper, InsP3R antikoerper, Ip3r antikoerper, Itpr-1 antikoerper, P400 antikoerper, Pcp-1 antikoerper, Pcp1 antikoerper, opt antikoerper, I145TR antikoerper, InsP3R1 antikoerper, INSP3R1 antikoerper, IP3R antikoerper, SCA15 antikoerper, SCA16 antikoerper, SCA29 antikoerper, inositol 1,4,5-trisphosphate receptor type 1 antikoerper, inositol 1,4,5-trisphosphate receptor 1 antikoerper, inositol 1,4,5-trisphosphate receptor, type 1 antikoerper, ITPR1 antikoerper, Itpr1 antikoerper

Hintergrund: Name/Gene ID: ITPR1
Subfamily: Inositol 1,4,5-triphosphate receptor
Family: Ion Channel

Synonyms: ITPR1, InsP3R-I, IP3R1, InsP3R, InsP3R type I, INSP3R1, IP3R, Opisthotonus, Pcp1, IP3 receptor, IP3 receptor isoform 1, SCA15, Spinocerebellar ataxia 15, Spinocerebellar ataxia 16, I145TR, IP3R 1, KIAA1754, SCA16, Type 1 InsP3 receptor

Gen-ID: 3708

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma