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HSP90 alpha/beta Antikörper (N-Term)

HSP90 alpha/beta Reaktivität: Human, Maus, Rind (Kuh) WB, IHC (p) Wirt: Maus Monoclonal MBH90AB unconjugated
Produktnummer ABIN343706
  • Target Alle HSP90 alpha/beta Produkte
    HSP90 alpha/beta (Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta))
    Bindungsspezifität
    • 12
    • 10
    • 2
    • 1
    • 1
    N-Term
    Reaktivität
    • 34
    • 27
    • 26
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Rind (Kuh)
    Wirt
    • 17
    • 14
    • 3
    Maus
    Klonalität
    • 17
    • 16
    Monoklonal
    Konjugat
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser HSP90 alpha/beta Antikörper ist unkonjugiert
    Applikation
    • 33
    • 30
    • 15
    • 8
    • 6
    • 6
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    The antibody MBH90AB recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta intracellular proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions.
    Kreuzreaktivität (Details)
    Human, Mouse, Bovine, Other not determined
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Peptide corresponding to the sequence EEVHHGEEEVEC within N-terminal part of human Hsp90.
    Klon
    MBH90AB
    Isotyp
    IgG1
  • Applikationshinweise
    Western blotting: Recommended dilution: 1 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Target
    HSP90 alpha/beta (Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta))
    Andere Bezeichnung
    Hsp90 alpha,beta (HSP90 alpha/beta Produkte)
    Hintergrund
    Hsp90 (heat shock protein 90) is one of the most abundant chaperones in the cytosol of eukaryotic cells. It interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis. There are two isoforms, alpha and beta, of vertebrate Hsp90. Whereas Hsp90 beta is expressed constitutively to a high level, Hsp90 alpha is stress-inducible and is overexpressed in many cancerous cells.,HSP90A, HSP90B, LAP-2, LAP2, EL52
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