MYB Antikörper (Internal Region)
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- Target Alle MYB Antikörper anzeigen
- MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MYB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with endogenous c-Myb protein and also SUMOylated overexpressed c-Myb protein in transfected Cos7 cells. A BLAST analysis was used to suggest reactivity with c-Myb from mouse based on a 100% homology with the immunizing sequence. Expect reactivity with c-Myb from rat, pig, human, horse, platypus, opossum, orangutan, spider monkey, bonobo, gorilla, and chimpanzee, with a v-myb myeloblastosis viral oncogene homolog, all isoforms (also avian version) from human, and with a protooncogene c-myb, and a v-myb myeloblastosis viral oncogene homolog (avian), both from cattle, all based on a 93% homology with the immunizing sequence. Cross-reactivity with c-Myb from other sources has not been determined.
- Produktmerkmale
- This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. The transcription factor c-Myb plays an important role in the development of all hematopoietic lineages during definitive hematopoiesis. Its critical role in hematopoiesis has been first demonstrated in experiments with targeted disruption of the c-Myb gene where deletion of both alleles of the c-Myb gene was embryonally lethal due to severe anemia. c-Myb is a short-lived sequence specific DNA-binding protein that regulates transcription of several important genes involved directly in cellular processes such as proliferation, differentiation, and apoptosis. Post-translational modifications such as phosphorylation, acetylation, ubiquitination, and conjugation of SUMO proteins are crucial for modulation of the transactivation activity of c-Myb.
- Aufreinigung
- affinity purified
- Sterilität
- Sterile filtered
- Immunogen
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This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal portion of mouse c-Myb protein.
Immunogen Type: Peptide - Isotyp
- IgG
- Top Product
- Discover our top product MYB Primärantikörper
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- Applikationshinweise
- This affinity purified antibody has been tested for use in ELISA and western blotting using M1 cells which express endogenous wild-type c-Myb protein and in COS7 cells transfected with c-Myb. Specific conditions for reactivity and detection of c-Myb should be optimized by the end user. Expect a band approximately ~75 kDa in size corresponding to c-Myb by western blotting in the appropriate cell lysate or extract.
- Kommentare
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Gene Name: MYB
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.0 mg/mL
- Buffer
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
- Haltbarkeit
- 3 months
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- Target
- MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))
- Andere Bezeichnung
- c-Myb (MYB Produkte)
- Synonyme
- Cmyb antikoerper, c-myb antikoerper, c-myb_CDS antikoerper, efg antikoerper, AI550390 antikoerper, M16449 antikoerper, cmyb antikoerper, xmyb antikoerper, MYB proto-oncogene, transcription factor antikoerper, myeloblastosis oncogene antikoerper, MYB proto-oncogene, transcription factor S homeolog antikoerper, v-myb avian myeloblastosis viral oncogene homolog antikoerper, MYB antikoerper, Myb antikoerper, myb.S antikoerper, myb antikoerper
- Hintergrund
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This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The transcription factor c-Myb plays an important role in the development of all hematopoietic lineages during definitive hematopoiesis. Its critical role in hematopoiesis has been first demonstrated in experiments with targeted disruption of the c-Myb gene where deletion of both alleles of the c-Myb gene was embryonally lethal due to severe anemia. c-Myb is a short-lived sequence specific DNA-binding protein that regulates transcription of several important genes involved directly in cellular processes such as proliferation, differentiation, and apoptosis. Post-translational modifications such as phosphorylation, acetylation, ubiquitination, and conjugation of SUMO proteins are crucial for modulation of the transactivation activity of c-Myb.
Synonyms: Avian myeloblastosis viral (v-myb) oncogene homolog antibody, C myb antibody, MYB antibody, v-myb avian myeloblastosis viral oncogene homolog antibody - Gen-ID
- 17863, 110556654
- UniProt
- P06876
- Pathways
- Chromatin Binding, Positive Regulation of Immune Effector Process
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