SERPINB2 Antikörper (Internal Region)

Produktnummer ABIN349627

Produktdetails anti-SERPINB2 Antikörper

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: This affinity-purified antibody is directed against human PAI-2 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification.  Reactivity occurs against human PAI-2 protein.   A BLAST analysis was used to suggest cross reactivity with PAI-2 proteins from several primates based on 94% homology with the immunizing sequence.  Reactivity against homologues from other sources is not known.

Kreuzreaktivität: Affe

Produktmerkmale: Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60-kDa, secreted, extracellular, glycosylated form and a 43-kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.

Aufreinigung: affinity purified

Sterilität: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal area of human PAI-2 protein.
Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band 42-46.6 kDa in size corresponding to PAI-2 protein by western blotting in the appropriate cell lysate or extract.

Kommentare:

Gene Name: SERPINB2

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.2 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

Haltbarkeit: 3 months

Referenzen für anti-SERPINB2 Antikörper (ABIN349627)

Godtfredsen, Sidelmann, Dolleris, Jørgensen, Johansen, Pedersen, Palarasah, Gram: "Fibrinolytic Changes in Women with Preeclampsia." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 28, pp. 10760296221126172, (2022) (PubMed).

Details zu SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Andere Bezeichnung: Plasminogen Activator Inhibitor 2 (SERPINB2 Produkte)

Synonyme: HsT1201 antikoerper, PAI antikoerper, PAI-2 antikoerper, PAI2 antikoerper, PLANH2 antikoerper, SERPINB2 antikoerper, Planh2 antikoerper, ovalbumin antikoerper, Pai2a antikoerper, serpin family B member 2 antikoerper, serpin peptidase inhibitor, clade B (ovalbumin), member 2 antikoerper, serine (or cysteine) peptidase inhibitor, clade B, member 2 antikoerper, SERPINB2 antikoerper, Serpinb2 antikoerper

Substanzklasse: Amino Acid

Hintergrund: Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor; Monocyte Arg-serpin; Urokinase inhibitor; SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60-kDa, secreted, extracellular, glycosylated form and a 43-kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.
Synonyms: PAI-2, Placental plasminogen activator inhibitor; Monocyte Arg-serpin; Urokinase inhibitor; SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2

Gen-ID: 5055, 4505595

UniProt: P05120

Pathways: Autophagie