NOS1 Antikörper (C-Term)

Produktnummer ABIN350524

Produktdetails anti-NOS1 Antikörper

Target: NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser NOS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for nNOS

Kreuzreaktivität: Meerschweinchen, Human, Maus, Kaninchen, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: Synthetic peptides from the c-terminal region of human nNOS conjugated to blue carrier protein was used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu NOS1

Target: NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))

Andere Bezeichnung: NOS1 (NOS1 Produkte)

Synonyme: NOS1 antikoerper, IHPS1 antikoerper, N-NOS antikoerper, NC-NOS antikoerper, NOS antikoerper, bNOS antikoerper, nNOS antikoerper, 2310005C01Rik antikoerper, NO antikoerper, NOS-I antikoerper, Nos-1 antikoerper, nos antikoerper, ihps1 antikoerper, nnos antikoerper, nos1 antikoerper, nos1-A antikoerper, nanos C2HC-type zinc finger 1 antikoerper, nitric oxide synthase 1 antikoerper, nitric oxide synthase 1, neuronal antikoerper, nitric oxide synthase 1 (neuronal) antikoerper, nitric oxide synthase 1 L homeolog antikoerper, NANOS1 antikoerper, NOS1 antikoerper, Nos1 antikoerper, nos1 antikoerper, nos1.L antikoerper

Hintergrund: FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. CATALYTIC ACTIVITY: L-arginine + n NADPH + m O2 = citrulline + nitric oxide + n NADP+. ENZYME REGULATION: Stimulated by calcium/calmodulin. Inhibited by n-Nos-inhibiting protein (PIN) which may prevent the dimerization of the protein. Inhibited by NOSIP. SUBCELLULAR LOCATION: Cell membrane, sarcolemma, Peripheral membrane protein. Cell projection, dendritic spine. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines. TISSUE SPECIFICITY: Isoform N-NOS-1 is expressed in brain and colorectum. Found in the Auerbach's plexus of the enteric nervous system. Isoform PNNOS is expressed in the penis, urethra, prostate, and skeletal muscle, and coexists with the cerebellar nnos in the pelvic plexus, bladder and liver, and is detectable in the cerebellum.,Neurotransmission,BNOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Constitutive NOS, NC-NOS, Nitric oxide synthase

UniProt: P29476

Pathways: Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction