NTRK3
(Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
Bindungsspezifität
pTyr820
Reaktivität
Human
Wirt
Schaf
Klonalität
Polyklonal
Konjugat
Dieser NTRK3 Antikörper ist unkonjugiert
Applikation
Western Blotting (WB), Immunohistochemistry (IHC)
Spezifität
Specific for TrkC.
Kreuzreaktivität
Human, Maus, Ratte
Kreuzreaktivität (Details)
Other species not yet tested.
Aufreinigung
IgG
Immunogen
A synthetic peptide to phospho Y820 of human TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
NTRK3
Reaktivität: Human
IHC, ELISA
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
Handhabung
Avoid freeze and thaw cycles.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Haltbarkeit
12 months
Target
NTRK3
(Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))
FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.,Neurotrophic Receptors,Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3