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MLL/KMT2A Antikörper (C-Term)

MLL Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN356674
  • Target Alle MLL/KMT2A (MLL) Antikörper anzeigen
    MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
    Bindungsspezifität
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 23
    • 12
    • 9
    Human
    Wirt
    • 18
    • 5
    Kaninchen
    Klonalität
    • 19
    • 4
    Polyklonal
    Konjugat
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MLL/KMT2A Antikörper ist unkonjugiert
    Applikation
    • 10
    • 9
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody is specific to HRX (C-term).
    Aufreinigung
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human HRX.
    Isotyp
    Ig Fraction
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  • Applikationshinweise
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
    Andere Bezeichnung
    MLL / HRX (MLL Produkte)
    Synonyme
    ALL-1 antikoerper, CXXC7 antikoerper, HRX antikoerper, HTRX1 antikoerper, MLL antikoerper, MLL/GAS7 antikoerper, MLL1A antikoerper, TET1-MLL antikoerper, TRX1 antikoerper, WDSTS antikoerper, 6430520K01 antikoerper, All1 antikoerper, Cxxc7 antikoerper, Mll antikoerper, Mll1 antikoerper, mKIAA4050 antikoerper, lysine methyltransferase 2A antikoerper, lysine (K)-specific methyltransferase 2A antikoerper, KMT2A antikoerper, Kmt2a antikoerper
    Hintergrund
    The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1,11)(q21,q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.Synonyms: ALL-1, ALL1, CXXC-type zinc finger protein 7, CXXC7, HTRX, Histone-lysine N-methyltransferase HRX, KMT2A, Lysine N-methyltransferase 2A, TRX1, Trithorax-like protein, Zinc finger protein HRX
    Gen-ID
    4297, 5874
    UniProt
    Q03164
    Pathways
    Warburg Effekt
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