SETD8 Antikörper (N-Term)

Produktnummer ABIN356687

Produktdetails anti-SETD8 Antikörper

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific to SET07 (N-term).

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SET07.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu SETD8

Target: SETD8 (SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))

Andere Bezeichnung: SETD8 / SET07 (SETD8 Produkte)

Synonyme: KMT5A antikoerper, PR-Set7 antikoerper, SET07 antikoerper, SET8 antikoerper, 2410195B05Rik antikoerper, AA617402 antikoerper, AW536475 antikoerper, PR-SET7 antikoerper, setd8b antikoerper, wu:fc23f12 antikoerper, zgc:171649 antikoerper, Pr-set7 antikoerper, RGD1305893 antikoerper, Setd8 antikoerper, kmt5a antikoerper, kmt5a-a antikoerper, setd8 antikoerper, setd8-a antikoerper, set8a antikoerper, setd8a antikoerper, wu:fj33f02 antikoerper, zgc:153719 antikoerper, lysine methyltransferase 5A antikoerper, lysine methyltransferase 5Ab antikoerper, lysine methyltransferase 5A S homeolog antikoerper, lysine methyltransferase 5Aa antikoerper, KMT5A antikoerper, Kmt5a antikoerper, kmt5ab antikoerper, kmt5a.S antikoerper, kmt5aa antikoerper

Hintergrund: SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity.Synonyms: H4-K20-HMTase SETD8, Histone-lysine N-methyltransferase SETD8, KMT5A, Lysine N-methyltransferase 5A, PR-Set7, PR/SET domain-containing protein 07, PRSET7, SET domain-containing protein 8, SET8

Gen-ID: 387893, 9606

UniProt: Q9NQR1