PIAS4 Antikörper (N-Term)

Produktnummer ABIN356770

Produktdetails anti-PIAS4 Antikörper

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIAS4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific to PIASy (N-term).

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIASy1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Reported to work in Immunoprecipitation (See Ref.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu PIAS4

Target: PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))

Andere Bezeichnung: PIAS4 (PIAS4 Produkte)

Synonyme: PIASY antikoerper, Piasg antikoerper, ZMIZ6 antikoerper, pias4 antikoerper, piasy antikoerper, wu:fc54c11 antikoerper, wu:fi18c10 antikoerper, wu:fi20e09 antikoerper, wu:fk93f11 antikoerper, zgc:66410 antikoerper, piasg antikoerper, zmiz6 antikoerper, LOC100219439 antikoerper, Pias-gamma antikoerper, pias4l antikoerper, wu:fi26h11 antikoerper, zgc:63923 antikoerper, protein inhibitor of activated STAT 4 antikoerper, protein inhibitor of activated STAT, 4 antikoerper, protein inhibitor of activated STAT, 4a antikoerper, protein inhibitor of activated STAT 4 L homeolog antikoerper, protein inhibitor of activated STAT, 4b antikoerper, PIAS4 antikoerper, Pias4 antikoerper, pias4a antikoerper, pias4.L antikoerper, pias4 antikoerper, pias4b antikoerper

Hintergrund: PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.Synonyms: E3 SUMO-protein ligase PIAS4, PIAS-gamma, PIASG, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma

Gen-ID: 51588, 9606

UniProt: Q8N2W9

Pathways: JAK-STAT Signalweg, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus