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SUMO4 Antikörper (Middle Region)

SUMO4 Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN356785
  • Target Alle SUMO4 Antikörper anzeigen
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Bindungsspezifität
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 48
    • 18
    • 18
    Human
    Wirt
    • 45
    • 3
    Kaninchen
    Klonalität
    • 38
    • 10
    Polyklonal
    Konjugat
    • 24
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser SUMO4 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 23
    • 20
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody is specific to SUMO4 (Center).
    Aufreinigung
    Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human SUMO4.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SUMO4 Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry on paraffin sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Andere Bezeichnung
    SUMO4 / SMT3H4 (SUMO4 Produkte)
    Synonyme
    IDDM5 antikoerper, SMT3H4 antikoerper, SUMO-4 antikoerper, dJ281H8.4 antikoerper, small ubiquitin-like modifier 4 antikoerper, small ubiquitin-related modifier 4 antikoerper, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antikoerper, SUMO4 antikoerper, sumo4 antikoerper
    Hintergrund
    SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.Synonyms: SUMO-4, Small ubiquitin-like protein 4, Small ubiquitin-related modifier 4
    Gen-ID
    387082, 9606
    UniProt
    Q6EEV6
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