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DKK2 Antikörper (N-Term)

DKK2 Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN357069
  • Target Alle DKK2 Antikörper anzeigen
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Bindungsspezifität
    • 9
    • 8
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 55
    • 15
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 50
    • 4
    • 1
    Kaninchen
    Klonalität
    • 51
    • 4
    Polyklonal
    Konjugat
    • 27
    • 8
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DKK2 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 29
    • 27
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects DKK2 at N-term.
    Aufreinigung
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DKK2.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DKK2 Primärantikörper
  • Applikationshinweise
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    DKK2 (Dickkopf 2 Homolog (DKK2))
    Andere Bezeichnung
    Dickkopf-2 (DKK2) (DKK2 Produkte)
    Synonyme
    DKK-2 antikoerper, Dkk4 antikoerper, zgc:171574 antikoerper, dickkopf WNT signaling pathway inhibitor 2 antikoerper, DKK2 antikoerper, Dkk2 antikoerper, dkk2 antikoerper
    Hintergrund
    The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.Synonyms: Dickkopf-related protein 2, Dkk-2
    Molekulargewicht
    28447 Da
    Gen-ID
    27123, 9606
    UniProt
    Q9UBU2
    Pathways
    WNT Signalweg
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