BMPR1A
Reaktivität: Human
WB, ELISA, IHC, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Target
BMPR1A
(Bone Morphogenetic Protein Receptor 1A (BMPR1A))
10q23del antikoerper, ACVRLK3 antikoerper, ALK3 antikoerper, CD292 antikoerper, SKR5 antikoerper, 1110037I22Rik antikoerper, AU045487 antikoerper, BMPR-IA antikoerper, Bmpr antikoerper, BMPR-1 antikoerper, BRK-1 antikoerper, BMPR1A antikoerper, acvrlk3 antikoerper, alk-3 antikoerper, alk3 antikoerper, cd292 antikoerper, skr5 antikoerper, BR1a antikoerper, alk3tr antikoerper, bmpr1a antikoerper, zgc:136731 antikoerper, wu:fe05b06 antikoerper, wu:fe06e10 antikoerper, zgc:92227 antikoerper, bone morphogenetic protein receptor type 1A antikoerper, bone morphogenetic protein receptor, type 1A antikoerper, bone morphogenetic protein receptor type 1A S homeolog antikoerper, bone morphogenetic protein receptor, type IAa antikoerper, bone morphogenetic protein receptor, type IAb antikoerper, BMPR1A antikoerper, Bmpr1a antikoerper, bmpr1a antikoerper, bmpr1a.S antikoerper, bmpr1aa antikoerper, bmpr1ab antikoerper
Hintergrund
The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH).Synonyms: ACVRLK3, ALK-3, ALK3, Activin receptor-like kinase 3, Bone morphogenetic protein receptor type-1A, SKR5, Serine/threonine-protein kinase receptor R5