Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SMURF2 Antikörper (N-Term)

SMURF2 Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN357471
  • Target Alle SMURF2 Antikörper anzeigen
    SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
    Bindungsspezifität
    • 16
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 66
    • 33
    • 20
    Human, Maus
    Wirt
    • 63
    • 3
    Kaninchen
    Klonalität
    • 54
    • 12
    Polyklonal
    Konjugat
    • 19
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMURF2 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 28
    • 24
    • 14
    • 13
    • 13
    • 13
    • 10
    • 7
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects SMURF2 at N-term.
    Aufreinigung
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SMURF2.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SMURF2 Primärantikörper
  • Applikationshinweise
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2))
    Andere Bezeichnung
    SMURF2 (SMURF2 Produkte)
    Synonyme
    SMURF2 antikoerper, 2810411E22Rik antikoerper, AI558114 antikoerper, AI649275 antikoerper, RGD1310067 antikoerper, wu:fb82a11 antikoerper, wu:fc41c02 antikoerper, SMAD specific E3 ubiquitin protein ligase 2 antikoerper, SMAD specific E3 ubiquitin protein ligase 2 S homeolog antikoerper, SMURF2 antikoerper, smurf2 antikoerper, Smurf2 antikoerper, smurf2.S antikoerper
    Hintergrund
    SMURF2, a 748-amino acid ubiquitin E3 ligase that is 83 % identical to SMURF1, codes for a C2-WW-HECT domain ubiquitin ligase that associates constitutively with SMAD7. Binding to SMAD7 induces export of SMURF2 and recruitment to the activated transforming growth factor-beta receptor (TGFBR), where it causes receptor and SMAD7 degradation. A strong interaction of second and third SMURF2 WW domains has been identified with SMAD1, SMAD2, and SMAD3, but not SMAD4. Western blot analysis showed that SMURF2 selectively downregulates the transcription of SMAD2 and SMAD1, but not SMAD3. The nuclear SMURF2/phosphorylated SMAD2 interaction is requires TGFB1.Synonyms: E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, SMURF 2, SMURF-2
    Molekulargewicht
    86195 Da
    Gen-ID
    64750
    NCBI Accession
    NP_073576
    UniProt
    Q9HAU4
Sie sind hier:
Kundenservice