USP14 Antikörper (N-Term)

Produktnummer ABIN357546

Produktdetails anti-USP14 Antikörper

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific to USP14 (N-term). Predicted to cross react with Mouse (100 % Antigen Homology).

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human USP14.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu USP14

Target: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Andere Bezeichnung: USP14 (USP14 Produkte)

Synonyme: TGT antikoerper, DDBDRAFT_0202821 antikoerper, DDBDRAFT_0237695 antikoerper, DDB_0202821 antikoerper, DDB_0237695 antikoerper, 2610005K12Rik antikoerper, 2610037B11Rik antikoerper, AW107924 antikoerper, C78769 antikoerper, ax antikoerper, zgc:55949 antikoerper, wu:fk63d09 antikoerper, MGC81945 antikoerper, tgt antikoerper, MGC69343 antikoerper, USP14 antikoerper, ubiquitin specific peptidase 14 antikoerper, peptidase C19 family protein antikoerper, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) antikoerper, ubiquitin specific protease 14 antikoerper, ubiquitin specific peptidase 14 S homeolog antikoerper, universal stress protein antikoerper, Ubiquitin carboxyl-terminal hydrolase 14 antikoerper, USP14 antikoerper, usp14 antikoerper, Usp14 antikoerper, Bm1_28765 antikoerper, usp14.S antikoerper, RR_RS06480 antikoerper, usp-14 antikoerper

Hintergrund: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.Synonyms: Deubiquitinating enzyme 14, TGT, Ubiquitin carboxyl-terminal hydrolase 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14

Molekulargewicht: 55938 Da

Gen-ID: 9097, 5874

UniProt: P54578