MIB1 Antikörper (N-Term)

Produktnummer ABIN357602

Produktdetails anti-MIB1 Antikörper

Target: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MIB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific to MIB1 (N-term). Predicted to cross react with Mouse and Zebrafish (100 % Antigen Homology).

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MIB.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100. Immunofluorescence: 1/20-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu MIB1

Target: MIB1 (Mindbomb E3 Ubiquitin Protein Ligase 1 (MIB1))

Andere Bezeichnung: MIB1 (MIB1 Produkte)

Synonyme: DIP-1 antikoerper, DIP1 antikoerper, LVNC7 antikoerper, MIB antikoerper, ZZANK2 antikoerper, ZZZ6 antikoerper, E430019M12Rik antikoerper, Mib antikoerper, mKIAA1323 antikoerper, dip-1 antikoerper, mib antikoerper, mindbomb antikoerper, cg5841 antikoerper, chunp6889 antikoerper, fe47f05 antikoerper, im:7148100 antikoerper, mib1 antikoerper, wu:fe47f05 antikoerper, CG5841 antikoerper, D-mib antikoerper, D-mib1 antikoerper, Dmel\CG5841 antikoerper, Dmib antikoerper, MIB1 antikoerper, Mib1 antikoerper, dmib1 antikoerper, l(3)72CDa antikoerper, l(3)72Db antikoerper, mib1/2 antikoerper, mind-bomb antikoerper, mindbomb E3 ubiquitin protein ligase 1 antikoerper, mindbomb E3 ubiquitin protein ligase 1 L homeolog antikoerper, mind bomb 1 antikoerper, MIB1 antikoerper, Mib1 antikoerper, mib1.L antikoerper, mib1 antikoerper

Hintergrund: MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.Synonyms: DAPK-interacting protein 1, DIP1, E3 ubiquitin-protein ligase MIB1, KIAA1323, Mind bomb homolog 1, ZZANK2, Zinc finger ZZ type with ankyrin repeat domain protein 2

Molekulargewicht: 110135 Da

Gen-ID: 57534, 9606

UniProt: Q86YT6

Pathways: SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion