CRY1 Antikörper (C-Term)

Produktnummer ABIN358613

Produktdetails anti-CRY1 Antikörper

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRY1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to CRY1.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide C-terminal region of human Cry1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu CRY1

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Andere Bezeichnung: Cryptochrome-1 (CRY1 Produkte)

Synonyme: cry1-A antikoerper, CRY1 antikoerper, cry2 antikoerper, phll1 antikoerper, xCRY1 antikoerper, PHLL1 antikoerper, AU020726 antikoerper, AU021000 antikoerper, Phll1 antikoerper, ATCRY1 antikoerper, BLU1 antikoerper, BLUE LIGHT UNINHIBITED 1 antikoerper, CRYPTOCHROME 1 APOPROTEIN (BLUE LIGHT PHOTORECEPTOR antikoerper, ELONGATED HYPOCOTYL 4 antikoerper, HY4 antikoerper, OOP2 antikoerper, OUT OF PHASE 2 antikoerper, T3H13.14 antikoerper, T3H13_14 antikoerper, cryptochrome 1 antikoerper, cryptochrome circadian clock 1 L homeolog antikoerper, cryptochrome circadian regulator 1 antikoerper, cryptochrome circadian clock 1 antikoerper, Cryptochrome-1 antikoerper, cryptochrome 1 antikoerper, cryptochrome 1 (photolyase-like) antikoerper, cry1.L antikoerper, CRY1 antikoerper, cry1 antikoerper, siu50817b antikoerper, Cry1 antikoerper

Hintergrund: Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.Synonyms: CRY1, PHLL1

Gen-ID: 1407, 9606

UniProt: Q16526

Pathways: Response to Water Deprivation, Proton Transport