LDLRAP1 Antikörper (C-Term)

Produktnummer ABIN360441

Produktdetails anti-LDLRAP1 Antikörper

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LDLRAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to ARH (LDLRAP1).

Aufreinigung: Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LDLRAP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu LDLRAP1

Target: LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))

Andere Bezeichnung: LDLRAP1 (LDLRAP1 Produkte)

Synonyme: ARH antikoerper, ARH1 antikoerper, ARH2 antikoerper, FHCB1 antikoerper, FHCB2 antikoerper, AA691260 antikoerper, Arh antikoerper, Arh1 antikoerper, RGD1563417 antikoerper, arh antikoerper, arh1 antikoerper, arh2 antikoerper, fhcb1 antikoerper, fhcb2 antikoerper, xptb antikoerper, LDLRAP1 antikoerper, ldlrap1 antikoerper, sb:cb50 antikoerper, zgc:56121 antikoerper, zgc:158745 antikoerper, low density lipoprotein receptor adaptor protein 1 antikoerper, low density lipoprotein receptor adaptor protein 1 L homeolog antikoerper, low density lipoprotein receptor adaptor protein 1 S homeolog antikoerper, low density lipoprotein receptor adaptor protein 1a antikoerper, low density lipoprotein receptor adaptor protein 1b antikoerper, LDLRAP1 antikoerper, Ldlrap1 antikoerper, ldlrap1 antikoerper, ldlrap1.L antikoerper, ldlrap1.S antikoerper, ldlrap1a antikoerper, ldlrap1b antikoerper

Hintergrund: LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. This adapter protein is required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. This protein may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits, and may also be involved in the internalization of other LDLR family members. Mutations in the LDLRAP1 gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.Synonyms: ARH, Autosomal recessive hypercholesterolemia protein, LDLRAP1, Low density lipoprotein receptor adapter protein 1

Gen-ID: 26119, 9606

UniProt: Q5SW96

Pathways: Lipid Metabolism