Lamin B2 Antikörper
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- Target Alle Lamin B2 (LMNB2) Antikörper anzeigen
- Lamin B2 (LMNB2)
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Reaktivität
- Human, Maus, Zebrafisch (Danio rerio), Xenopus laevis, Hamster, Schwein
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Lamin B2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- Reacts with an epitope located in the C-terminal part of Lamin B2.
- Aufreinigung
- Purified
- Immunogen
- Detergent insoluble fraction of potoroo cell line PtK1.
- Klon
- LN43
- Isotyp
- IgG1
- Top Product
- Discover our top product LMNB2 Primärantikörper
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- Applikationshinweise
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Suitable for Immunocytochemistry on Frozen Sections, Immunoblotting and FlowCytometry. Recommended Dilutions: 1/100-1/200 for Flow cytometry and for Immunohistochemistry with avidin-biotinylatedhorseradish peroxidase complex (ABC) as detection reagent.1/100-1/1000 for Immunoblotting applications.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- PBS with 0.09 % Sodium Azide as preservative.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store lyophilized at 2 - 8 °C and reconstituted at -20 °C.
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- Target
- Lamin B2 (LMNB2)
- Andere Bezeichnung
- Lamin-B2 (LMNB2) (LMNB2 Produkte)
- Synonyme
- lmnb2-a antikoerper, LMNB2 antikoerper, lmn2 antikoerper, lamb2 antikoerper, Lamin-L(II) antikoerper, LOC100136040 antikoerper, im:7142331 antikoerper, lamin antikoerper, wu:fb94e05 antikoerper, wu:fb95e12 antikoerper, wu:fc15d06 antikoerper, wu:fc49h03 antikoerper, lamin-b2 antikoerper, lmnb2 antikoerper, LAMB2 antikoerper, LMN2 antikoerper, RGD1563803 antikoerper, lamin B2 S homeolog antikoerper, lamin B2 antikoerper, lamin B2 L homeolog antikoerper, lmnb2.S antikoerper, LMNB2 antikoerper, lmnb2 antikoerper, lmnb2.L antikoerper, Lmnb2 antikoerper
- Hintergrund
- An important part of the cell nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of a-helices and a carboxyterminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus. Besides interactions with the nuclear membrane and other intermediate filaments, lamins interact with the nuclear chromatin. Eukaryotic chromatin is organised into loops, which are attached to the nuclear matrix. This organisation is thought to contribute to compaction of the chromatin and regulation of gene expression. Lamins, as part of the nuclear matrix, may be involved in these processes since chromatin binding sites have been detected in both A- and B-type lamins.Synonyms: LMN2, LMNB, LMNB-2, LMNB2, Lamin-B2, Nuclear Envelope Marker
- Gen-ID
- 84823
- NCBI Accession
- NP_116126
- UniProt
- Q03252
- Pathways
- Apoptose, Caspase Kaskade in der Apoptose
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