Choline Acetyltransferase Antikörper

Produktnummer ABIN361419

Produktdetails anti-Choline Acetyltransferase Antikörper

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Choline Acetyltransferase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for the ~ 70k choline acetyltransferase protein

Kreuzreaktivität: Vogel, Huhn, Meerschweinchen, Human, Maus, Non-Human Primate

Aufreinigung: Affinity Purified

Immunogen: Native choline acetyltransferase purifed from human placenta

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:100 IHC: 1:100 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu Choline Acetyltransferase

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Andere Bezeichnung: CHAT (CHAT Produkte)

Hintergrund: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999). Anti-Choline Acetyltransferase Western blot of rat brain lysate showing specific immunolabeling of the ~70k ChAT

Molekulargewicht: '70 kDa

Gen-ID: 1103

Pathways: Skeletal Muscle Fiber Development