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DARPP32 Antikörper (N-Term)
PPP1R1B
Reaktivität: Ratte
WB, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-DARPP32 Antikörper
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Target
Alle DARPP32 (PPP1R1B) Antikörper anzeigen
DARPP32 (PPP1R1B)
(Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B))
Bindungsspezifität
Alle Epitope für DARPP32 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für DARPP32 Antikörper
Ratte
Wirt
Alle Wirte für DARPP32 Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für DARPP32 Antikörper
Polyklonal
Konjugat
Alle Konjugate für DARPP32 Antikörper
Dieser DARPP32 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für DARPP32 Antikörper
Western Blotting (WB), Immunohistochemistry (IHC)
Spezifität
Specific for the ~32k DARPP-32 protein.
Kreuzreaktivität
Ratte (Rattus)
Homologie
bovine, canine, chicken, human, mouse, non-human primate, Xenopus
Aufreinigung
Antigen Affinity Purified from Pooled Serum
Immunogen
Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
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Alternativen
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Anwendungsinformationen
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Applikationshinweise
Recommended Dilution: WB: 1:1000 IHC: 1:250 Quality Control: Western blots performed on each lot.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Lagerung
-20 °C
Referenzen für anti-DARPP32 Antikörper (ABIN361423)
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Gomez, Midde, Mactutus, Booze, Zhu : "Environmental enrichment alters nicotine-mediated locomotor sensitization and phosphorylation of DARPP-32 and CREB in rat prefrontal cortex. " in: PLoS ONE , Vol. 7 , Issue 8 , pp. e44149 , (2013 ) (PubMed ).
Details zu DARPP32
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Target
DARPP32 (PPP1R1B)
(Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B (PPP1R1B))
Andere Bezeichnung
PPP1R1B (PPP1R1B Produkte )
Synonyme
darpp32 antikoerper, darpp-32 antikoerper, Darpp-32 antikoerper, Darpp32 antikoerper, DARPP-32 antikoerper, DARPP32 antikoerper, AU040756 antikoerper, protein phosphatase 1 regulatory inhibitor subunit 1B antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 1B antikoerper, protein phosphatase 1 regulatory inhibitor subunit 1B S homeolog antikoerper, ppp1r1b antikoerper, PPP1R1B antikoerper, Ppp1r1b antikoerper, ppp1r1b.S antikoerper
Hintergrund
DARPP-32 is a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons (Fienberg et al., 1998). The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA (Bibb et al., 1999). Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac® (Maldve et al., 2002, Lindskog et al., 2002, Svenningsson et al., 2002). Anti-DARPP-32 Western blot of a rat hippocampal lysate showing specific immunolabeling of the ~32k DARPP protein.
Molekulargewicht
'32 kDa
Gen-ID
360616
UniProt
Q6J4I0
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