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GABRA3 Antikörper (N-Term)

GABRA3 Reaktivität: Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN361437
  • Target Alle GABRA3 Antikörper anzeigen
    GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
    Bindungsspezifität
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 29
    • 26
    • 23
    • 10
    • 9
    • 8
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Ratte
    Wirt
    • 31
    • 1
    • 1
    • 1
    Kaninchen
    Klonalität
    • 33
    • 1
    Polyklonal
    Konjugat
    • 27
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GABRA3 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 11
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Specific for the ~51k a3-subunit of the GABAA receptor in Western blots. Labeling is absent in a3-subunit knockout animals.
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Homologie
    bovine, canine, human, non-human primates, Zebrafish
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Synthetic peptide from the N-terminal region of the alpha 3 subunit
    Top Product
    Discover our top product GABRA3 Primärantikörper
  • Applikationshinweise
    Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Lagerung
    -20 °C
  • Target
    GABRA3 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 3 (GABRA3))
    Andere Bezeichnung
    GABRA3 (GABRA3 Produkte)
    Synonyme
    GABRA3 antikoerper, Gabra-3 antikoerper, si:ch211-113k9.1 antikoerper, gamma-aminobutyric acid type A receptor alpha3 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, alpha 3 antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 antikoerper, gamma-aminobutyric acid receptor subunit alpha-3 antikoerper, GABRA3 antikoerper, gabra3 antikoerper, Gabra3 antikoerper, LOC100653496 antikoerper
    Hintergrund
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, fourbetas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and gamma-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a -subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). Anti-GABAA-Receptor, 3 -Subunit Western blot of mouse brain lysates from wild type (Control) and a3-knockout (aK/O) animals showing specific immunolabeling of the ~51k a3-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a3-knockout animals.
    Molekulargewicht
    '51 kDa
    Gen-ID
    24947
    UniProt
    P20236
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