The antibody detects endogenous level of Elk1 only when phosphorylated at serine 389.
Aufreinigung
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Immunogen
Peptide sequence around phosphorylation site of pSer389 (P-R-S (p) -P-A) derived from Human Elk-1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Elk-1 antikoerper, Xelk antikoerper, Xelk-1 antikoerper, elk-1 antikoerper, elk1 antikoerper, ELK1, ETS transcription factor antikoerper, ELK1, member of ETS oncogene family antikoerper, ETS domain-containing protein Elk-1 antikoerper, ELK1, member of ETS oncogene family S homeolog antikoerper, ELK1 antikoerper, Elk1 antikoerper, Tsp_02690 antikoerper, elk1 antikoerper, elk1.S antikoerper
Hintergrund
Elk-1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene